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STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS
A specific disease entity was established in white mice by the nasal instillation of lung and exudate suspensions from each of 14 adult albino rats affected with endemic pneumonia. The induced disease was characterized by pneumonia (96 per cent), otitis media (94 per cent), and rhinitis (30 per cent...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1946
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135637/ https://www.ncbi.nlm.nih.gov/pubmed/19871555 |
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author | Nelson, John B. |
author_facet | Nelson, John B. |
author_sort | Nelson, John B. |
collection | PubMed |
description | A specific disease entity was established in white mice by the nasal instillation of lung and exudate suspensions from each of 14 adult albino rats affected with endemic pneumonia. The induced disease was characterized by pneumonia (96 per cent), otitis media (94 per cent), and rhinitis (30 per cent). It progressed slowly after an incubation period of 7 to 14 days and was attended by a variable mortality which reached 33 per cent in 22 weeks. Maintenance of the disease was regularly accomplished by direct transmission from mouse to mouse but only by the nasal route and only from the three foci of involvement. It was also transmissible by direct contact but required a prolonged period of exposure. The relation of the disease to infectious catarrh, which it closely resembles, is discussed. |
format | Text |
id | pubmed-2135637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1946 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21356372008-04-18 STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS Nelson, John B. J Exp Med Article A specific disease entity was established in white mice by the nasal instillation of lung and exudate suspensions from each of 14 adult albino rats affected with endemic pneumonia. The induced disease was characterized by pneumonia (96 per cent), otitis media (94 per cent), and rhinitis (30 per cent). It progressed slowly after an incubation period of 7 to 14 days and was attended by a variable mortality which reached 33 per cent in 22 weeks. Maintenance of the disease was regularly accomplished by direct transmission from mouse to mouse but only by the nasal route and only from the three foci of involvement. It was also transmissible by direct contact but required a prolonged period of exposure. The relation of the disease to infectious catarrh, which it closely resembles, is discussed. The Rockefeller University Press 1946-06-30 /pmc/articles/PMC2135637/ /pubmed/19871555 Text en Copyright © Copyright, 1946, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Nelson, John B. STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS |
title | STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS |
title_full | STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS |
title_fullStr | STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS |
title_full_unstemmed | STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS |
title_short | STUDIES ON ENDEMIC PNEUMONIA OF THE ALBINO RAT : I. THE TRANSMISSION OF A COMMUNICABLE DISEASE TO MICE FROM NATURALLY INFECTED RATS |
title_sort | studies on endemic pneumonia of the albino rat : i. the transmission of a communicable disease to mice from naturally infected rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135637/ https://www.ncbi.nlm.nih.gov/pubmed/19871555 |
work_keys_str_mv | AT nelsonjohnb studiesonendemicpneumoniaofthealbinoratithetransmissionofacommunicablediseasetomicefromnaturallyinfectedrats |