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EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS
Continued in vitro cultivation in a Maitland type medium resulted in a marked modification of the extraneural pathogenicity of the Venezuelan equine encephalomyelitis virus. The ability of the virus to induce lethal infections after peripheral inoculation was almost completely lost for mice 42 or mo...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1946
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135649/ https://www.ncbi.nlm.nih.gov/pubmed/19871564 |
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author | Koprowski, Hilary Lennette, Edwin H. |
author_facet | Koprowski, Hilary Lennette, Edwin H. |
author_sort | Koprowski, Hilary |
collection | PubMed |
description | Continued in vitro cultivation in a Maitland type medium resulted in a marked modification of the extraneural pathogenicity of the Venezuelan equine encephalomyelitis virus. The ability of the virus to induce lethal infections after peripheral inoculation was almost completely lost for mice 42 or more days of age, was somewhat reduced for mice 28 days of age, but was still retained for mice 21 or less days of age. The virulence of the virus by the cerebral route remained essentially unaffected for mice of any of the experimental age groups. Prolonged cultivation also resulted in almost complete attenuation of the virus for rabbits and guinea pigs by the intraperitoneal route. |
format | Text |
id | pubmed-2135649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1946 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21356492008-04-18 EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS Koprowski, Hilary Lennette, Edwin H. J Exp Med Article Continued in vitro cultivation in a Maitland type medium resulted in a marked modification of the extraneural pathogenicity of the Venezuelan equine encephalomyelitis virus. The ability of the virus to induce lethal infections after peripheral inoculation was almost completely lost for mice 42 or more days of age, was somewhat reduced for mice 28 days of age, but was still retained for mice 21 or less days of age. The virulence of the virus by the cerebral route remained essentially unaffected for mice of any of the experimental age groups. Prolonged cultivation also resulted in almost complete attenuation of the virus for rabbits and guinea pigs by the intraperitoneal route. The Rockefeller University Press 1946-08-31 /pmc/articles/PMC2135649/ /pubmed/19871564 Text en Copyright © Copyright, 1946, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Koprowski, Hilary Lennette, Edwin H. EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS |
title | EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS |
title_full | EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS |
title_fullStr | EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS |
title_full_unstemmed | EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS |
title_short | EFFECT OF IN VITRO CULTIVATION ON THE PATHOGENICITY OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS |
title_sort | effect of in vitro cultivation on the pathogenicity of venezuelan equine encephalomyelitis virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135649/ https://www.ncbi.nlm.nih.gov/pubmed/19871564 |
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