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CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM
The inhibition of virus multiplication by 5-methyl tryptophane can be specifically reversed by tryptophane. The conditions of reversal indicate that 5MT specifically interferes with tryptophane utilization. The tryptophane requirements of virus multiplication appear to exist throughout the latent pe...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1947
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135687/ https://www.ncbi.nlm.nih.gov/pubmed/19871649 |
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author | Cohen, Seymour S. Fowler, Catherine B. |
author_facet | Cohen, Seymour S. Fowler, Catherine B. |
author_sort | Cohen, Seymour S. |
collection | PubMed |
description | The inhibition of virus multiplication by 5-methyl tryptophane can be specifically reversed by tryptophane. The conditions of reversal indicate that 5MT specifically interferes with tryptophane utilization. The tryptophane requirements of virus multiplication appear to exist throughout the latent period and determine the time of lysis and amount of virus liberated. A latent period may be interrupted for 15 minutes or more and be resumed on addition of tryptophane. Extended inhibition with 5MT results in a somewhat variable "killing" effect, the extent of which determines aspects of the reversal of the inhibition by tryptophane. The implications of these phenomena have been discussed. |
format | Text |
id | pubmed-2135687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1947 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21356872008-04-18 CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM Cohen, Seymour S. Fowler, Catherine B. J Exp Med Article The inhibition of virus multiplication by 5-methyl tryptophane can be specifically reversed by tryptophane. The conditions of reversal indicate that 5MT specifically interferes with tryptophane utilization. The tryptophane requirements of virus multiplication appear to exist throughout the latent period and determine the time of lysis and amount of virus liberated. A latent period may be interrupted for 15 minutes or more and be resumed on addition of tryptophane. Extended inhibition with 5MT results in a somewhat variable "killing" effect, the extent of which determines aspects of the reversal of the inhibition by tryptophane. The implications of these phenomena have been discussed. The Rockefeller University Press 1947-05-31 /pmc/articles/PMC2135687/ /pubmed/19871649 Text en Copyright © Copyright, 1947, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Cohen, Seymour S. Fowler, Catherine B. CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM |
title | CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM |
title_full | CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM |
title_fullStr | CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM |
title_full_unstemmed | CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM |
title_short | CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM |
title_sort | chemical studies on host-virus interactions : iii. tryptophane requirements in the stages of virus multiplication in the escherichia coli-t2 bacteriophage system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135687/ https://www.ncbi.nlm.nih.gov/pubmed/19871649 |
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