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ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS

1. The spontaneous mast cell tumor of the dog contains heparin. 2. The cytoplasmic particulate content of the tumor mast cells varies with their anaplasia. This conclusion is based on the following findings: (a) in the immature cell of the more malignant tumor the particulate matter appeared in the...

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Autores principales: Oliver, Jean, Bloom, Frank, Mangieri, Carmen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1947
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135713/
https://www.ncbi.nlm.nih.gov/pubmed/19871658
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author Oliver, Jean
Bloom, Frank
Mangieri, Carmen
author_facet Oliver, Jean
Bloom, Frank
Mangieri, Carmen
author_sort Oliver, Jean
collection PubMed
description 1. The spontaneous mast cell tumor of the dog contains heparin. 2. The cytoplasmic particulate content of the tumor mast cells varies with their anaplasia. This conclusion is based on the following findings: (a) in the immature cell of the more malignant tumor the particulate matter appeared in the living cells by phase microscopy to be composed of greyish illdefined particles or as a fine, weakly metachromatic granulation in the fixed and stained preparation; (b) in the mature cells of a relatively benign mast cell tumor, both in the living cell and in stained preparations, the particulate matter occurred in the form of discrete, dense, and strongly metachromatic granules, resembling those of the normal mast cell. 3. The heparin content was large (fifty times that of dog liver) in the growth with mature cells and only moderate (1.7 times) in that with immature cells. 4. Since there may be a great amount of greyish particulate matter (or fine stained granules) in a tumor of relatively low heparin content, it is suggested that this material represents an early or precursor phase in the development of heparin. 5. This possibility and the fact that the blood stream may be invaded by mature tumor mast cells of large heparin content without evident disturbance in the coagulability of the blood suggest the value of a comprehensive biochemical study of the heparin of mast cell tumors.
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spelling pubmed-21357132008-04-18 ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS Oliver, Jean Bloom, Frank Mangieri, Carmen J Exp Med Article 1. The spontaneous mast cell tumor of the dog contains heparin. 2. The cytoplasmic particulate content of the tumor mast cells varies with their anaplasia. This conclusion is based on the following findings: (a) in the immature cell of the more malignant tumor the particulate matter appeared in the living cells by phase microscopy to be composed of greyish illdefined particles or as a fine, weakly metachromatic granulation in the fixed and stained preparation; (b) in the mature cells of a relatively benign mast cell tumor, both in the living cell and in stained preparations, the particulate matter occurred in the form of discrete, dense, and strongly metachromatic granules, resembling those of the normal mast cell. 3. The heparin content was large (fifty times that of dog liver) in the growth with mature cells and only moderate (1.7 times) in that with immature cells. 4. Since there may be a great amount of greyish particulate matter (or fine stained granules) in a tumor of relatively low heparin content, it is suggested that this material represents an early or precursor phase in the development of heparin. 5. This possibility and the fact that the blood stream may be invaded by mature tumor mast cells of large heparin content without evident disturbance in the coagulability of the blood suggest the value of a comprehensive biochemical study of the heparin of mast cell tumors. The Rockefeller University Press 1947-07-31 /pmc/articles/PMC2135713/ /pubmed/19871658 Text en Copyright © Copyright, 1947, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Oliver, Jean
Bloom, Frank
Mangieri, Carmen
ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS
title ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS
title_full ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS
title_fullStr ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS
title_full_unstemmed ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS
title_short ON THE ORIGIN OF HEPARIN : AN EXAMINATION OF THE HEPARIN CONTENT AND THE SPECIFIC CYTOPLASMIC PARTICLES OF NEOPLASTIC MAST CELLS
title_sort on the origin of heparin : an examination of the heparin content and the specific cytoplasmic particles of neoplastic mast cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135713/
https://www.ncbi.nlm.nih.gov/pubmed/19871658
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