PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION

A procedure has been detailed for the preparation of sterile non-pyrogenic solutions of oxyhemoglobin which have the approximate protein content and electrolyte composition of plasma. Large volumes of solution can be rapidly prepared, with 95 to 98 per cent of the hemoglobin in the active form capab...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamilton, Paul B., Farr, Lee E., Hiller, Alma, Van Slyke, Donald D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1947
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135755/
https://www.ncbi.nlm.nih.gov/pubmed/19871690
_version_ 1782142969461080064
author Hamilton, Paul B.
Farr, Lee E.
Hiller, Alma
Van Slyke, Donald D.
author_facet Hamilton, Paul B.
Farr, Lee E.
Hiller, Alma
Van Slyke, Donald D.
author_sort Hamilton, Paul B.
collection PubMed
description A procedure has been detailed for the preparation of sterile non-pyrogenic solutions of oxyhemoglobin which have the approximate protein content and electrolyte composition of plasma. Large volumes of solution can be rapidly prepared, with 95 to 98 per cent of the hemoglobin in the active form capable of combining with oxygen. The solutions contain no particulate matter; 95 per cent of total blood lipids are removed. Solutions stored at 4°C. showed no conversion of hemoglobin to methemoglobin over a period of 2½ months; over a 6 month period a small and variable amount of methemoglobin may be formed.
format Text
id pubmed-2135755
institution National Center for Biotechnology Information
language English
publishDate 1947
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21357552008-04-18 PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION Hamilton, Paul B. Farr, Lee E. Hiller, Alma Van Slyke, Donald D. J Exp Med Article A procedure has been detailed for the preparation of sterile non-pyrogenic solutions of oxyhemoglobin which have the approximate protein content and electrolyte composition of plasma. Large volumes of solution can be rapidly prepared, with 95 to 98 per cent of the hemoglobin in the active form capable of combining with oxygen. The solutions contain no particulate matter; 95 per cent of total blood lipids are removed. Solutions stored at 4°C. showed no conversion of hemoglobin to methemoglobin over a period of 2½ months; over a 6 month period a small and variable amount of methemoglobin may be formed. The Rockefeller University Press 1947-11-30 /pmc/articles/PMC2135755/ /pubmed/19871690 Text en Copyright © Copyright, 1947, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Hamilton, Paul B.
Farr, Lee E.
Hiller, Alma
Van Slyke, Donald D.
PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION
title PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION
title_full PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION
title_fullStr PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION
title_full_unstemmed PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION
title_short PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION
title_sort preparation of hemoglobin solutions for intravenous infusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135755/
https://www.ncbi.nlm.nih.gov/pubmed/19871690
work_keys_str_mv AT hamiltonpaulb preparationofhemoglobinsolutionsforintravenousinfusion
AT farrleee preparationofhemoglobinsolutionsforintravenousinfusion
AT hilleralma preparationofhemoglobinsolutionsforintravenousinfusion
AT vanslykedonaldd preparationofhemoglobinsolutionsforintravenousinfusion

Ejemplares similares