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STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS

Complement-fixing antibodies to the cytoplasmic particles (CP) and to the S fraction of streptococcal nucleoproteins are present in normal human sera, the range of concentrations varying among the age groups. The titer of these antibodies rises between the first half-week and the 3rd week of scarlet...

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Autor principal: Harris, T. N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1948
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135761/
https://www.ncbi.nlm.nih.gov/pubmed/19871699
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author Harris, T. N.
author_facet Harris, T. N.
author_sort Harris, T. N.
collection PubMed
description Complement-fixing antibodies to the cytoplasmic particles (CP) and to the S fraction of streptococcal nucleoproteins are present in normal human sera, the range of concentrations varying among the age groups. The titer of these antibodies rises between the first half-week and the 3rd week of scarlet fever, in more than 80 per cent of the cases. The titers then remain elevated for at least 4 months. In children, 91 per cent of the normal sera examined showed anti-CP titers up to 32; 87 per cent of sera in active rheumatic disease had titers above this level. Corresponding data with S fell in the same range of percentage distribution. Anti-CP and anti-S titers remained elevated long after the rheumatic process had reached quiescence. No correlation of serologic titer with the degree of clinical activity was found in the case of either antibody.
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spelling pubmed-21357612008-04-18 STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS Harris, T. N. J Exp Med Article Complement-fixing antibodies to the cytoplasmic particles (CP) and to the S fraction of streptococcal nucleoproteins are present in normal human sera, the range of concentrations varying among the age groups. The titer of these antibodies rises between the first half-week and the 3rd week of scarlet fever, in more than 80 per cent of the cases. The titers then remain elevated for at least 4 months. In children, 91 per cent of the normal sera examined showed anti-CP titers up to 32; 87 per cent of sera in active rheumatic disease had titers above this level. Corresponding data with S fell in the same range of percentage distribution. Anti-CP and anti-S titers remained elevated long after the rheumatic process had reached quiescence. No correlation of serologic titer with the degree of clinical activity was found in the case of either antibody. The Rockefeller University Press 1948-01-01 /pmc/articles/PMC2135761/ /pubmed/19871699 Text en Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Harris, T. N.
STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS
title STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS
title_full STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS
title_fullStr STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS
title_full_unstemmed STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS
title_short STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER : III. COMPLEMENT FIXATION VERSUS STREPTOCOCCAL NUCLEOPROTEINS WITH THE SERA OF PATIENTS WITH RHEUMATIC FEVER AND OTHERS
title_sort studies in the relation of the hemolytic streptococcus to rheumatic fever : iii. complement fixation versus streptococcal nucleoproteins with the sera of patients with rheumatic fever and others
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135761/
https://www.ncbi.nlm.nih.gov/pubmed/19871699
work_keys_str_mv AT harristn studiesintherelationofthehemolyticstreptococcustorheumaticfeveriiicomplementfixationversusstreptococcalnucleoproteinswiththeseraofpatientswithrheumaticfeverandothers