THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION

Polysaccharides derived from type-specific Friedländer bacilli cause inhibition of the multiplication of mumps virus in the allantoic sac of the chick embryo. As little as 5 µg. of polysaccharide is effective as an inhibitor. Inhibition of multiplication is obtained when polysaccharide is injected a...

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Detalles Bibliográficos
Autores principales: Ginsberg, Harold S., Goebel, Walther F., Horsfall, Frank L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1948
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135788/
https://www.ncbi.nlm.nih.gov/pubmed/18912891
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author Ginsberg, Harold S.
Goebel, Walther F.
Horsfall, Frank L.
author_facet Ginsberg, Harold S.
Goebel, Walther F.
Horsfall, Frank L.
author_sort Ginsberg, Harold S.
collection PubMed
description Polysaccharides derived from type-specific Friedländer bacilli cause inhibition of the multiplication of mumps virus in the allantoic sac of the chick embryo. As little as 5 µg. of polysaccharide is effective as an inhibitor. Inhibition of multiplication is obtained when polysaccharide is injected as long as 4 days after inoculation of virus. Chemical studies have shown that the structural configurations of the polysaccharide responsible for specific serological activity are not identical with those which determine the inhibitory effect relative to mumps virus. The possible mechanisms of the inhibition of viral multiplication by means of polysaccharides are discussed.
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spelling pubmed-21357882008-04-18 THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION Ginsberg, Harold S. Goebel, Walther F. Horsfall, Frank L. J Exp Med Article Polysaccharides derived from type-specific Friedländer bacilli cause inhibition of the multiplication of mumps virus in the allantoic sac of the chick embryo. As little as 5 µg. of polysaccharide is effective as an inhibitor. Inhibition of multiplication is obtained when polysaccharide is injected as long as 4 days after inoculation of virus. Chemical studies have shown that the structural configurations of the polysaccharide responsible for specific serological activity are not identical with those which determine the inhibitory effect relative to mumps virus. The possible mechanisms of the inhibition of viral multiplication by means of polysaccharides are discussed. The Rockefeller University Press 1948-05-01 /pmc/articles/PMC2135788/ /pubmed/18912891 Text en Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ginsberg, Harold S.
Goebel, Walther F.
Horsfall, Frank L.
THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION
title THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION
title_full THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION
title_fullStr THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION
title_full_unstemmed THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION
title_short THE INHIBITORY EFFECT OF POLYSACCHARIDE ON MUMPS VIRUS MULTIPLICATION
title_sort inhibitory effect of polysaccharide on mumps virus multiplication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135788/
https://www.ncbi.nlm.nih.gov/pubmed/18912891
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