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THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS
Human sera taken at various stages of mumps have been analyzed in regard to their reactivity with two serologically distinct complement fixation antigens which were derived from the infected chick embryo. Antibodies to the soluble or S antigen appear earlier in the disease and, as a rule, reach high...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1948
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135801/ https://www.ncbi.nlm.nih.gov/pubmed/18871883 |
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author | Henle, Gertrude Harris, Susanna Henle, Werner |
author_facet | Henle, Gertrude Harris, Susanna Henle, Werner |
author_sort | Henle, Gertrude |
collection | PubMed |
description | Human sera taken at various stages of mumps have been analyzed in regard to their reactivity with two serologically distinct complement fixation antigens which were derived from the infected chick embryo. Antibodies to the soluble or S antigen appear earlier in the disease and, as a rule, reach high levels before antibodies against the virus-bound or V antigen commence to rise. In early convalescence, both antibodies reach high levels. Subsequently antibodies against the S antigen decrease usually at a faster rate than those against V, so that after a period of several years, frequently only anti-V may be left. These findings were found helpful in diagnostic procedures. The use of both the V and S antigens has permitted the early diagnosis of manifestations of mumps in the absence of parotitis, such as meningoencephalitis, since the finding of high levels of anti-S and of low titers of, or no, anti-V is considered diagnostically significant for the first few days of illness. For the determination of resistance the use of the V antigen appears more useful. Following vaccination or skin testing, antibodies against both antigens may develop; those against V increase more regularly and to higher titers than those against S. |
format | Text |
id | pubmed-2135801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1948 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21358012008-04-18 THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS Henle, Gertrude Harris, Susanna Henle, Werner J Exp Med Article Human sera taken at various stages of mumps have been analyzed in regard to their reactivity with two serologically distinct complement fixation antigens which were derived from the infected chick embryo. Antibodies to the soluble or S antigen appear earlier in the disease and, as a rule, reach high levels before antibodies against the virus-bound or V antigen commence to rise. In early convalescence, both antibodies reach high levels. Subsequently antibodies against the S antigen decrease usually at a faster rate than those against V, so that after a period of several years, frequently only anti-V may be left. These findings were found helpful in diagnostic procedures. The use of both the V and S antigens has permitted the early diagnosis of manifestations of mumps in the absence of parotitis, such as meningoencephalitis, since the finding of high levels of anti-S and of low titers of, or no, anti-V is considered diagnostically significant for the first few days of illness. For the determination of resistance the use of the V antigen appears more useful. Following vaccination or skin testing, antibodies against both antigens may develop; those against V increase more regularly and to higher titers than those against S. The Rockefeller University Press 1948-07-01 /pmc/articles/PMC2135801/ /pubmed/18871883 Text en Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Henle, Gertrude Harris, Susanna Henle, Werner THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS |
title | THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS |
title_full | THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS |
title_fullStr | THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS |
title_full_unstemmed | THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS |
title_short | THE REACTIVITY OF VARIOUS HUMAN SERA WITH MUMPS COMPLEMENT FIXATION ANTIGENS |
title_sort | reactivity of various human sera with mumps complement fixation antigens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135801/ https://www.ncbi.nlm.nih.gov/pubmed/18871883 |
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