THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI

All preparations of sphingomyelin tested, whatever the tissues from which they originated, were found to enhance the growth of tubercle bacilli in vitro. Cerebrosides were inactive in this respect. Sphingomyelin promotes growth through two independent mechanisms: (a) It neutralizes the toxicity of l...

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Autor principal: Dubos, René J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1948
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135804/
https://www.ncbi.nlm.nih.gov/pubmed/18871879
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author Dubos, René J.
author_facet Dubos, René J.
author_sort Dubos, René J.
collection PubMed
description All preparations of sphingomyelin tested, whatever the tissues from which they originated, were found to enhance the growth of tubercle bacilli in vitro. Cerebrosides were inactive in this respect. Sphingomyelin promotes growth through two independent mechanisms: (a) It neutralizes the toxicity of long chain fatty acids probably by forming with them inert complexes. This protective effect facilitates initiation of growth from small inocula. (b) It supplies to the bacteria lignoceric acid (or its amide) which is utilized for growth. The base sphingosine, another component of sphingomyelin, does not favor and probably inhibits proliferation of tubercle bacilli.
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spelling pubmed-21358042008-04-18 THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI Dubos, René J. J Exp Med Article All preparations of sphingomyelin tested, whatever the tissues from which they originated, were found to enhance the growth of tubercle bacilli in vitro. Cerebrosides were inactive in this respect. Sphingomyelin promotes growth through two independent mechanisms: (a) It neutralizes the toxicity of long chain fatty acids probably by forming with them inert complexes. This protective effect facilitates initiation of growth from small inocula. (b) It supplies to the bacteria lignoceric acid (or its amide) which is utilized for growth. The base sphingosine, another component of sphingomyelin, does not favor and probably inhibits proliferation of tubercle bacilli. The Rockefeller University Press 1948-07-01 /pmc/articles/PMC2135804/ /pubmed/18871879 Text en Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dubos, René J.
THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI
title THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI
title_full THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI
title_fullStr THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI
title_full_unstemmed THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI
title_short THE EFFECT OF SPHINGOMYELIN ON THE GROWTH OF TUBERCLE BACILLI
title_sort effect of sphingomyelin on the growth of tubercle bacilli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135804/
https://www.ncbi.nlm.nih.gov/pubmed/18871879
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