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LEPTOSPIROSIS IN CATTLE
From abnormal milk of cows an agent has been transmitted to guinea pigs, rabbits, mice, and embryonated eggs. This agent caused a febrile reaction in guinea pigs and rabbits and an inapparent infection in mice. In early passages embryonated eggs were unaffected but later death of embryos occurred 7...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1948
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135826/ https://www.ncbi.nlm.nih.gov/pubmed/18881488 |
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author | Baker, James A. Little, Ralph B. |
author_facet | Baker, James A. Little, Ralph B. |
author_sort | Baker, James A. |
collection | PubMed |
description | From abnormal milk of cows an agent has been transmitted to guinea pigs, rabbits, mice, and embryonated eggs. This agent caused a febrile reaction in guinea pigs and rabbits and an inapparent infection in mice. In early passages embryonated eggs were unaffected but later death of embryos occurred 7 days after inoculation. When blood from infected guinea pigs or chorioallantoic fluid from infected eggs was inoculated subcutaneously or intranasally into young calves, fever with albuminuria and more rarely hemoglobinuria was produced, in lactating cows the infection resembled that seen in animals with natural disease. Pen contact of normal cows and calves with infected calves resulted in inapparent infection. Autopsies showed that in addition to causing altered milk secretion, the agent damaged the kidneys and produced an interstitial nephritis. The agent was recovered from blood and milk during the febrile period and was demonstrated in the urine for periods long afterwards. Antibodies for the spirochete were found in the sera of experimental animals and of cows recovered from the natural disease. The blood of infected guinea pigs, the chorioallantoic fluid from infected eggs, and the blood or urine from experimentally infected calves yielded a culture of a spirochete which appeared identical with the infective agent in comparative tests of physical, pathogenic, and immunological properties. |
format | Text |
id | pubmed-2135826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1948 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21358262008-04-18 LEPTOSPIROSIS IN CATTLE Baker, James A. Little, Ralph B. J Exp Med Article From abnormal milk of cows an agent has been transmitted to guinea pigs, rabbits, mice, and embryonated eggs. This agent caused a febrile reaction in guinea pigs and rabbits and an inapparent infection in mice. In early passages embryonated eggs were unaffected but later death of embryos occurred 7 days after inoculation. When blood from infected guinea pigs or chorioallantoic fluid from infected eggs was inoculated subcutaneously or intranasally into young calves, fever with albuminuria and more rarely hemoglobinuria was produced, in lactating cows the infection resembled that seen in animals with natural disease. Pen contact of normal cows and calves with infected calves resulted in inapparent infection. Autopsies showed that in addition to causing altered milk secretion, the agent damaged the kidneys and produced an interstitial nephritis. The agent was recovered from blood and milk during the febrile period and was demonstrated in the urine for periods long afterwards. Antibodies for the spirochete were found in the sera of experimental animals and of cows recovered from the natural disease. The blood of infected guinea pigs, the chorioallantoic fluid from infected eggs, and the blood or urine from experimentally infected calves yielded a culture of a spirochete which appeared identical with the infective agent in comparative tests of physical, pathogenic, and immunological properties. The Rockefeller University Press 1948-09-01 /pmc/articles/PMC2135826/ /pubmed/18881488 Text en Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Baker, James A. Little, Ralph B. LEPTOSPIROSIS IN CATTLE |
title | LEPTOSPIROSIS IN CATTLE |
title_full | LEPTOSPIROSIS IN CATTLE |
title_fullStr | LEPTOSPIROSIS IN CATTLE |
title_full_unstemmed | LEPTOSPIROSIS IN CATTLE |
title_short | LEPTOSPIROSIS IN CATTLE |
title_sort | leptospirosis in cattle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135826/ https://www.ncbi.nlm.nih.gov/pubmed/18881488 |
work_keys_str_mv | AT bakerjamesa leptospirosisincattle AT littleralphb leptospirosisincattle |