OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION

The relationship of the fever caused in rabbits by bacterial pyrogens to the fever produced by the injection of the sterile exudates of acute inflammation was investigated by recording the responses of normal and pyrogen-tolerant animals to injections of exudate. Exudates were produced by the intrap...

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Autor principal: Bennett, Ivan L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1948
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135827/
https://www.ncbi.nlm.nih.gov/pubmed/18881486
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author Bennett, Ivan L.
author_facet Bennett, Ivan L.
author_sort Bennett, Ivan L.
collection PubMed
description The relationship of the fever caused in rabbits by bacterial pyrogens to the fever produced by the injection of the sterile exudates of acute inflammation was investigated by recording the responses of normal and pyrogen-tolerant animals to injections of exudate. Exudates were produced by the intrapleural injection of turpentine in dogs. The duration of the febrile response in rabbits after a single dose of exudate was found to be much shorter than the fever following an injection of bacterial pyrogen. Animals given daily injections of exudate demonstrated no tolerance to its fever-promoting effect. Animals tolerant to bacterial pyrogens showed no diminution in responsiveness to exudates. Daily injections of exudate failed to establish tolerance to bacterial pyrogens in rabbits. It is concluded that the fever-promoting property of sterile exudates is not due to the presence of bacterial pyrogen.
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spelling pubmed-21358272008-04-18 OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION Bennett, Ivan L. J Exp Med Article The relationship of the fever caused in rabbits by bacterial pyrogens to the fever produced by the injection of the sterile exudates of acute inflammation was investigated by recording the responses of normal and pyrogen-tolerant animals to injections of exudate. Exudates were produced by the intrapleural injection of turpentine in dogs. The duration of the febrile response in rabbits after a single dose of exudate was found to be much shorter than the fever following an injection of bacterial pyrogen. Animals given daily injections of exudate demonstrated no tolerance to its fever-promoting effect. Animals tolerant to bacterial pyrogens showed no diminution in responsiveness to exudates. Daily injections of exudate failed to establish tolerance to bacterial pyrogens in rabbits. It is concluded that the fever-promoting property of sterile exudates is not due to the presence of bacterial pyrogen. The Rockefeller University Press 1948-09-01 /pmc/articles/PMC2135827/ /pubmed/18881486 Text en Copyright © Copyright, 1948, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bennett, Ivan L.
OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION
title OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION
title_full OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION
title_fullStr OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION
title_full_unstemmed OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION
title_short OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS : II. A STUDY OF THE RELATIONSHIP BETWEEN THE FEVERS CAUSED BY BACTERIAL PYROGENS AND BY THE INTRAVENOUS INJECTION OF THE STERILE EXUDATES OF ACUTE INFLAMMATION
title_sort observations on the fever caused by bacterial pyrogens : ii. a study of the relationship between the fevers caused by bacterial pyrogens and by the intravenous injection of the sterile exudates of acute inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135827/
https://www.ncbi.nlm.nih.gov/pubmed/18881486
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