OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE

1. Pregnancy enhances the susceptibility of the rat to intercurrent renal damage produced by anti-placenta serum. This is manifested by the development of renal hypertrophy and nephritis in a number of these animals. Both renal hypertrophy and nephritis are consistently intensified by the concomitan...

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Detalles Bibliográficos
Autores principales: Loeb, Emily N., Knowlton, Abbie I., Stoerk, Herbert C., Seegal, Beatrice C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1949
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135867/
https://www.ncbi.nlm.nih.gov/pubmed/18110883
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author Loeb, Emily N.
Knowlton, Abbie I.
Stoerk, Herbert C.
Seegal, Beatrice C.
author_facet Loeb, Emily N.
Knowlton, Abbie I.
Stoerk, Herbert C.
Seegal, Beatrice C.
author_sort Loeb, Emily N.
collection PubMed
description 1. Pregnancy enhances the susceptibility of the rat to intercurrent renal damage produced by anti-placenta serum. This is manifested by the development of renal hypertrophy and nephritis in a number of these animals. Both renal hypertrophy and nephritis are consistently intensified by the concomitant administration of DCA. 2. Hypertension develops in both pregnant and non-pregnant rats treated with the anti-placenta serum employed together with the daily administration of DCA. 3. Termination of pregnancy, in the face of continued DCA administration, fails to lower the blood pressure or to arrest the nephritic process.
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spelling pubmed-21358672008-04-17 OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE Loeb, Emily N. Knowlton, Abbie I. Stoerk, Herbert C. Seegal, Beatrice C. J Exp Med Article 1. Pregnancy enhances the susceptibility of the rat to intercurrent renal damage produced by anti-placenta serum. This is manifested by the development of renal hypertrophy and nephritis in a number of these animals. Both renal hypertrophy and nephritis are consistently intensified by the concomitant administration of DCA. 2. Hypertension develops in both pregnant and non-pregnant rats treated with the anti-placenta serum employed together with the daily administration of DCA. 3. Termination of pregnancy, in the face of continued DCA administration, fails to lower the blood pressure or to arrest the nephritic process. The Rockefeller University Press 1949-02-28 /pmc/articles/PMC2135867/ /pubmed/18110883 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Loeb, Emily N.
Knowlton, Abbie I.
Stoerk, Herbert C.
Seegal, Beatrice C.
OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE
title OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE
title_full OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE
title_fullStr OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE
title_full_unstemmed OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE
title_short OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE
title_sort observations on the pregnant rat injected with nephrotoxic rabbit anti-rat placenta serum and desoxycorticosterone acetate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135867/
https://www.ncbi.nlm.nih.gov/pubmed/18110883
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