ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS

Acquisition by pneumococcal variants of M protein and of capsular polysaccharide different from those present in the parent strain has been effected in vitro by means of transforming reactions with extracts of heterologous encapsulated pneumococci. Similar transformations have been accomplished in v...

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Detalles Bibliográficos
Autores principales: Austrian, Robert, MacLeod, Colin M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1949
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135878/
https://www.ncbi.nlm.nih.gov/pubmed/18124620
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author Austrian, Robert
MacLeod, Colin M.
author_facet Austrian, Robert
MacLeod, Colin M.
author_sort Austrian, Robert
collection PubMed
description Acquisition by pneumococcal variants of M protein and of capsular polysaccharide different from those present in the parent strain has been effected in vitro by means of transforming reactions with extracts of heterologous encapsulated pneumococci. Similar transformations have been accomplished in vivo with heat-killed vaccines as the transforming agents. Independent variation of pneumococcal capsular polysaccharide and M protein observed in nature can be brought about also in the laboratory. By means of transforming reactions, it has been demonstrated that inheritable characters of three distinct pneumococcal strains can be combined within a single strain. It is suggested that acquisition of M protein through transformation reactions occurs in cells deficient in that character.
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spelling pubmed-21358782008-04-17 ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS Austrian, Robert MacLeod, Colin M. J Exp Med Article Acquisition by pneumococcal variants of M protein and of capsular polysaccharide different from those present in the parent strain has been effected in vitro by means of transforming reactions with extracts of heterologous encapsulated pneumococci. Similar transformations have been accomplished in vivo with heat-killed vaccines as the transforming agents. Independent variation of pneumococcal capsular polysaccharide and M protein observed in nature can be brought about also in the laboratory. By means of transforming reactions, it has been demonstrated that inheritable characters of three distinct pneumococcal strains can be combined within a single strain. It is suggested that acquisition of M protein through transformation reactions occurs in cells deficient in that character. The Rockefeller University Press 1949-03-31 /pmc/articles/PMC2135878/ /pubmed/18124620 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Austrian, Robert
MacLeod, Colin M.
ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS
title ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS
title_full ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS
title_fullStr ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS
title_full_unstemmed ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS
title_short ACQUISITION OF M PROTEIN BY PNEUMOCOCCI THROUGH TRANSFORMATION REACTIONS
title_sort acquisition of m protein by pneumococci through transformation reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135878/
https://www.ncbi.nlm.nih.gov/pubmed/18124620
work_keys_str_mv AT austrianrobert acquisitionofmproteinbypneumococcithroughtransformationreactions
AT macleodcolinm acquisitionofmproteinbypneumococcithroughtransformationreactions

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