Cargando…

CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN

Granulomatous lesions of the valves and valve rings have been produced in 52 per cent of rabbits treated by massive intravenous administrations of bovine gamma globulin in such a way as to establish a state of anaphylactic hypersensitivity in the animals. The incidence of the lesions is greater than...

Descripción completa

Detalles Bibliográficos
Autores principales: More, Robert H., Waugh, Douglas, Kobernick, Sidney D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1949
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135886/
https://www.ncbi.nlm.nih.gov/pubmed/18120095
_version_ 1782142999799529472
author More, Robert H.
Waugh, Douglas
Kobernick, Sidney D.
author_facet More, Robert H.
Waugh, Douglas
Kobernick, Sidney D.
author_sort More, Robert H.
collection PubMed
description Granulomatous lesions of the valves and valve rings have been produced in 52 per cent of rabbits treated by massive intravenous administrations of bovine gamma globulin in such a way as to establish a state of anaphylactic hypersensitivity in the animals. The incidence of the lesions is greater than has heretofore been reported as produced by the use of any type of foreign protein injection in rabbits. The use of a purified protein antigen has resulted in the production of several different types of lesions; namely, a granulomatous inflammation of heart valves and valve rings, a glomerulonephritis, and an arteritis. The lesions of the heart cannot be regarded as being identical with the lesions of human rheumatic fever, but they are considered to be sufficiently similar to warrant a continuation of this approach to the study of the etiology and pathogenesis of rheumatic fever in man.
format Text
id pubmed-2135886
institution National Center for Biotechnology Information
language English
publishDate 1949
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21358862008-04-17 CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN More, Robert H. Waugh, Douglas Kobernick, Sidney D. J Exp Med Article Granulomatous lesions of the valves and valve rings have been produced in 52 per cent of rabbits treated by massive intravenous administrations of bovine gamma globulin in such a way as to establish a state of anaphylactic hypersensitivity in the animals. The incidence of the lesions is greater than has heretofore been reported as produced by the use of any type of foreign protein injection in rabbits. The use of a purified protein antigen has resulted in the production of several different types of lesions; namely, a granulomatous inflammation of heart valves and valve rings, a glomerulonephritis, and an arteritis. The lesions of the heart cannot be regarded as being identical with the lesions of human rheumatic fever, but they are considered to be sufficiently similar to warrant a continuation of this approach to the study of the etiology and pathogenesis of rheumatic fever in man. The Rockefeller University Press 1949-04-30 /pmc/articles/PMC2135886/ /pubmed/18120095 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
More, Robert H.
Waugh, Douglas
Kobernick, Sidney D.
CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN
title CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN
title_full CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN
title_fullStr CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN
title_full_unstemmed CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN
title_short CARDIAC LESIONS PRODUCED IN RABBITS BY MASSIVE INJECTIONS OF BOVINE SERUM GAMMA GLOBULIN
title_sort cardiac lesions produced in rabbits by massive injections of bovine serum gamma globulin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135886/
https://www.ncbi.nlm.nih.gov/pubmed/18120095
work_keys_str_mv AT moreroberth cardiaclesionsproducedinrabbitsbymassiveinjectionsofbovineserumgammaglobulin
AT waughdouglas cardiaclesionsproducedinrabbitsbymassiveinjectionsofbovineserumgammaglobulin
AT kobernicksidneyd cardiaclesionsproducedinrabbitsbymassiveinjectionsofbovineserumgammaglobulin