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QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION
1. Pulmonary tuberculosis in unselected rabbits, induced by primary quantitative air-borne infection with human type tubercle bacilli, may retrogress or progress. Some animals whose disease was in a stationary condition might have fallen into one of the above groups had the experiments been prolonge...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1949
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135897/ https://www.ncbi.nlm.nih.gov/pubmed/18129861 |
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author | Heppleston, A. G. |
author_facet | Heppleston, A. G. |
author_sort | Heppleston, A. G. |
collection | PubMed |
description | 1. Pulmonary tuberculosis in unselected rabbits, induced by primary quantitative air-borne infection with human type tubercle bacilli, may retrogress or progress. Some animals whose disease was in a stationary condition might have fallen into one of the above groups had the experiments been prolonged. 2. Within the limits of the observations natural resistance or susceptibility appears to be the chief factor in determining the course of the disease. 3. Following the development of the primary lesions the tuberculin reaction became positive but thereafter proved to be an unreliable indicator of the course of the disease. 4. Tubercle bacilli can be recovered from macroscopically normal lung tissue of rabbits several weeks after primary infection. 5. Reinfection did not induce the formation of new lesions nor alter the course of the disease caused by the primary infection. |
format | Text |
id | pubmed-2135897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1949 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21358972008-04-17 QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION Heppleston, A. G. J Exp Med Article 1. Pulmonary tuberculosis in unselected rabbits, induced by primary quantitative air-borne infection with human type tubercle bacilli, may retrogress or progress. Some animals whose disease was in a stationary condition might have fallen into one of the above groups had the experiments been prolonged. 2. Within the limits of the observations natural resistance or susceptibility appears to be the chief factor in determining the course of the disease. 3. Following the development of the primary lesions the tuberculin reaction became positive but thereafter proved to be an unreliable indicator of the course of the disease. 4. Tubercle bacilli can be recovered from macroscopically normal lung tissue of rabbits several weeks after primary infection. 5. Reinfection did not induce the formation of new lesions nor alter the course of the disease caused by the primary infection. The Rockefeller University Press 1949-05-31 /pmc/articles/PMC2135897/ /pubmed/18129861 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Heppleston, A. G. QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION |
title | QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION |
title_full | QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION |
title_fullStr | QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION |
title_full_unstemmed | QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION |
title_short | QUANTITATIVE AIR-BORNE TUBERCULOSIS IN THE RABBIT : THE COURSE OF HUMAN TYPE INFECTION |
title_sort | quantitative air-borne tuberculosis in the rabbit : the course of human type infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135897/ https://www.ncbi.nlm.nih.gov/pubmed/18129861 |
work_keys_str_mv | AT hepplestonag quantitativeairbornetuberculosisintherabbitthecourseofhumantypeinfection |