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A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE

Serial passage of mumps virus in the presence of inhibitory quantities of the capsular polysaccharide of Friediänder bacillus type B results in the appearance of a variant strain of the virus. Multiplication of the variant virus is not inhibited by the polysaccharide. A similar resistant variant is...

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Detalles Bibliográficos
Autores principales: Ginsberg, Harold S., Horsfall, Frank L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1949
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135925/
https://www.ncbi.nlm.nih.gov/pubmed/18143585
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author Ginsberg, Harold S.
Horsfall, Frank L.
author_facet Ginsberg, Harold S.
Horsfall, Frank L.
author_sort Ginsberg, Harold S.
collection PubMed
description Serial passage of mumps virus in the presence of inhibitory quantities of the capsular polysaccharide of Friediänder bacillus type B results in the appearance of a variant strain of the virus. Multiplication of the variant virus is not inhibited by the polysaccharide. A similar resistant variant is obtained with polysaccharide in a single cycle of multiplication when very large inocula of mumps virus are employed. The resistant variant is indistinguishable from the parent strain as to infectivity, reactivity with erythrocytes, and immunological properties, but appears to have a somewhat slower rate of multiplication. Serial passage of the resistant variant in the absence of polysaccharide results in the reappearance of a sensitive strain. It is suggested that mumps virus populations are inhomogeneous; that naturally occurring variants are present in such populations and possess distinctive properties; that the use of a chemical inhibitor of mumps virus multiplication makes possible the selection of a variant possessing a predictable property. The findings are discussed in relation to the mechanism of inhibition of mumps virus multiplication by polysaccharide.
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spelling pubmed-21359252008-04-17 A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE Ginsberg, Harold S. Horsfall, Frank L. J Exp Med Article Serial passage of mumps virus in the presence of inhibitory quantities of the capsular polysaccharide of Friediänder bacillus type B results in the appearance of a variant strain of the virus. Multiplication of the variant virus is not inhibited by the polysaccharide. A similar resistant variant is obtained with polysaccharide in a single cycle of multiplication when very large inocula of mumps virus are employed. The resistant variant is indistinguishable from the parent strain as to infectivity, reactivity with erythrocytes, and immunological properties, but appears to have a somewhat slower rate of multiplication. Serial passage of the resistant variant in the absence of polysaccharide results in the reappearance of a sensitive strain. It is suggested that mumps virus populations are inhomogeneous; that naturally occurring variants are present in such populations and possess distinctive properties; that the use of a chemical inhibitor of mumps virus multiplication makes possible the selection of a variant possessing a predictable property. The findings are discussed in relation to the mechanism of inhibition of mumps virus multiplication by polysaccharide. The Rockefeller University Press 1949-10-31 /pmc/articles/PMC2135925/ /pubmed/18143585 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ginsberg, Harold S.
Horsfall, Frank L.
A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE
title A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE
title_full A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE
title_fullStr A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE
title_full_unstemmed A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE
title_short A RESISTANT VARIANT OF MUMPS VIRUS : MULTIPLICATION OF THE VARIANT IN THE PRESENCE OF INHIBITORY QUANTITIES OF FRIEDLÄNDER BACILLUS POLYSACCHARIDE
title_sort resistant variant of mumps virus : multiplication of the variant in the presence of inhibitory quantities of friedländer bacillus polysaccharide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135925/
https://www.ncbi.nlm.nih.gov/pubmed/18143585
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