A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT

A labile component present in the serum of human beings, guinea pigs, and rabbits neutralizes the infectivity of mumps, Newcastle disease, influenza A and B viruses. The labile component of these sera and of mouse serum also inhibits hemagglutination of chicken RBC by these viruses. The component is...

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Detalles Bibliográficos
Autores principales: Ginsberg, Harold S., Horsfall, Frank L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1949
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135926/
https://www.ncbi.nlm.nih.gov/pubmed/18143590
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author Ginsberg, Harold S.
Horsfall, Frank L.
author_facet Ginsberg, Harold S.
Horsfall, Frank L.
author_sort Ginsberg, Harold S.
collection PubMed
description A labile component present in the serum of human beings, guinea pigs, and rabbits neutralizes the infectivity of mumps, Newcastle disease, influenza A and B viruses. The labile component of these sera and of mouse serum also inhibits hemagglutination of chicken RBC by these viruses. The component is inactivated by heating at 56°C. for 30 minutes and upon storage at 4°C. for periods longer than 2 weeks. The virus-neutralizing and hemagglutination-inhibiting properties result from serum component-virus combination in the presence of calcium. The combination is stable, and does not undergo spontaneous dissociation. Partial separation of virus can be brought about by heating mixtures held for 24 hours or by removal of calcium ions with sodium citrate. The labile serum component appears to be distinct from hemolytic complement.
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spelling pubmed-21359262008-04-17 A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT Ginsberg, Harold S. Horsfall, Frank L. J Exp Med Article A labile component present in the serum of human beings, guinea pigs, and rabbits neutralizes the infectivity of mumps, Newcastle disease, influenza A and B viruses. The labile component of these sera and of mouse serum also inhibits hemagglutination of chicken RBC by these viruses. The component is inactivated by heating at 56°C. for 30 minutes and upon storage at 4°C. for periods longer than 2 weeks. The virus-neutralizing and hemagglutination-inhibiting properties result from serum component-virus combination in the presence of calcium. The combination is stable, and does not undergo spontaneous dissociation. Partial separation of virus can be brought about by heating mixtures held for 24 hours or by removal of calcium ions with sodium citrate. The labile serum component appears to be distinct from hemolytic complement. The Rockefeller University Press 1949-10-31 /pmc/articles/PMC2135926/ /pubmed/18143590 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ginsberg, Harold S.
Horsfall, Frank L.
A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT
title A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT
title_full A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT
title_fullStr A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT
title_full_unstemmed A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT
title_short A LABILE COMPONENT OF NORMAL SERUM WHICH COMBINES WITH VARIOUS VIRUSES. NEUTRALIZATION OF INFECTIVITY AND INHIBITION OF HEMAGGLUTINATION BY THE COMPONENT
title_sort labile component of normal serum which combines with various viruses. neutralization of infectivity and inhibition of hemagglutination by the component
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135926/
https://www.ncbi.nlm.nih.gov/pubmed/18143590
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