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THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA

Rabbit antisera against partially purified streptococcal desoxyribonuclease inhibit the action of the enzyme on its substrate. The activity of pancreatic desoxyribonuclease is not affected by these antisera. Similarly antibody against pancreatic nuclease does not inhibit the streptococcal enzyme. Ce...

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Detalles Bibliográficos
Autor principal: McCarty, Maclyn
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1949
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135932/
https://www.ncbi.nlm.nih.gov/pubmed/15394072
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author McCarty, Maclyn
author_facet McCarty, Maclyn
author_sort McCarty, Maclyn
collection PubMed
description Rabbit antisera against partially purified streptococcal desoxyribonuclease inhibit the action of the enzyme on its substrate. The activity of pancreatic desoxyribonuclease is not affected by these antisera. Similarly antibody against pancreatic nuclease does not inhibit the streptococcal enzyme. Certain patients develop inhibitory antibody to streptococcal desoxyribonuclease following streptococcal infections, occasionally in very high titer, although the proportion of patients showing an antibody response appears to be lower than in the case of streptokinase and streptolysin O. The pattern of antibody response to desoxyribonuclease has been compared to that of streptokinase and streptolysin O in a group of ninety patients from an epidemic of scarlet fever.
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spelling pubmed-21359322008-04-17 THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA McCarty, Maclyn J Exp Med Article Rabbit antisera against partially purified streptococcal desoxyribonuclease inhibit the action of the enzyme on its substrate. The activity of pancreatic desoxyribonuclease is not affected by these antisera. Similarly antibody against pancreatic nuclease does not inhibit the streptococcal enzyme. Certain patients develop inhibitory antibody to streptococcal desoxyribonuclease following streptococcal infections, occasionally in very high titer, although the proportion of patients showing an antibody response appears to be lower than in the case of streptokinase and streptolysin O. The pattern of antibody response to desoxyribonuclease has been compared to that of streptokinase and streptolysin O in a group of ninety patients from an epidemic of scarlet fever. The Rockefeller University Press 1949-11-30 /pmc/articles/PMC2135932/ /pubmed/15394072 Text en Copyright © Copyright, 1949, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McCarty, Maclyn
THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA
title THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA
title_full THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA
title_fullStr THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA
title_full_unstemmed THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA
title_short THE INHIBITION OF STREPTOCOCCAL DESOXYRIBONUCLEASE BY RABBIT AND HUMAN ANTISERA
title_sort inhibition of streptococcal desoxyribonuclease by rabbit and human antisera
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135932/
https://www.ncbi.nlm.nih.gov/pubmed/15394072
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