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STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE

In rhesus and cynomolgus monkeys without signs or symptoms of poliomyelitis, a comparison of the incidence, numbers, size, and character of lesions in certain peripheral ganglia (gasserian, nodose, superior cervical sympathetic, and celiac) was made between 9 "new" animals sacrificed 1 to...

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Autores principales: Faber, Harold K., Silverberg, Rosalie J., Dong, Luther
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135974/
https://www.ncbi.nlm.nih.gov/pubmed/19871717
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author Faber, Harold K.
Silverberg, Rosalie J.
Dong, Luther
author_facet Faber, Harold K.
Silverberg, Rosalie J.
Dong, Luther
author_sort Faber, Harold K.
collection PubMed
description In rhesus and cynomolgus monkeys without signs or symptoms of poliomyelitis, a comparison of the incidence, numbers, size, and character of lesions in certain peripheral ganglia (gasserian, nodose, superior cervical sympathetic, and celiac) was made between 9 "new" animals sacrificed 1 to 3 days after arrival in a laboratory devoted exclusively to poliomyelitis research, and 17 "old" animals housed there without special isolation precautions for periods ranging from 17 days to 10½ months. The comparison showed that the "old" animals had more infiltrative lesions of various sizes than the "new" and that neuronophagia occurred in 65 per cent of the "old" animals as compared with none in the "new." The heaviest and most frequent involvement occurred in the gasserian and superior cervical sympathetic ganglia, while that of the nodose (vagal afferent) ganglia was somewhat less, and that of the celiac ganglia was still less and without neurophagia. The ganglia of the VII and IX cranial nerves were also examined and showed no lesions of note. Reasons are presented for believing that the lesions were of centripetal and not of centrifugal origin. The lesions, while not positively identified as poliomyelitic, were of similar morphology, were presumably due to an infective neurotropic agent, and were acquired under conditions of potential exposure to poliomyelitis virus. The possibility is suggested that the asymptomatic acquisition of neurotropic lesions in this group of casually exposed monkeys can be comparable to the acquisition of "subclinical" poliomyelitis in man.
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spelling pubmed-21359742008-04-17 STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE Faber, Harold K. Silverberg, Rosalie J. Dong, Luther J Exp Med Article In rhesus and cynomolgus monkeys without signs or symptoms of poliomyelitis, a comparison of the incidence, numbers, size, and character of lesions in certain peripheral ganglia (gasserian, nodose, superior cervical sympathetic, and celiac) was made between 9 "new" animals sacrificed 1 to 3 days after arrival in a laboratory devoted exclusively to poliomyelitis research, and 17 "old" animals housed there without special isolation precautions for periods ranging from 17 days to 10½ months. The comparison showed that the "old" animals had more infiltrative lesions of various sizes than the "new" and that neuronophagia occurred in 65 per cent of the "old" animals as compared with none in the "new." The heaviest and most frequent involvement occurred in the gasserian and superior cervical sympathetic ganglia, while that of the nodose (vagal afferent) ganglia was somewhat less, and that of the celiac ganglia was still less and without neurophagia. The ganglia of the VII and IX cranial nerves were also examined and showed no lesions of note. Reasons are presented for believing that the lesions were of centripetal and not of centrifugal origin. The lesions, while not positively identified as poliomyelitic, were of similar morphology, were presumably due to an infective neurotropic agent, and were acquired under conditions of potential exposure to poliomyelitis virus. The possibility is suggested that the asymptomatic acquisition of neurotropic lesions in this group of casually exposed monkeys can be comparable to the acquisition of "subclinical" poliomyelitis in man. The Rockefeller University Press 1950-03-31 /pmc/articles/PMC2135974/ /pubmed/19871717 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Faber, Harold K.
Silverberg, Rosalie J.
Dong, Luther
STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE
title STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE
title_full STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE
title_fullStr STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE
title_full_unstemmed STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE
title_short STUDIES ON THE ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : I. NEUTROTROPIC INFECTION OF THE PERIPHERAL GANGLIA IN APPARENTLY HEALTHY MONKEYS FOLLOWING CASUAL EXPOSURE
title_sort studies on the entry and egress of poliomyelitic infection : i. neutrotropic infection of the peripheral ganglia in apparently healthy monkeys following casual exposure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135974/
https://www.ncbi.nlm.nih.gov/pubmed/19871717
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