THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE

Cardiac lesions like those characteristic of rheumatic fever in man have been induced in a small portion of rabbits that were subjected to successive focal infections with group A streptococci of several serological types. Fresh myocardial interstitial granulomata so induced bear striking resemblanc...

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Detalles Bibliográficos
Autores principales: Murphy, George E., Swift, Homer F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135981/
https://www.ncbi.nlm.nih.gov/pubmed/15415504
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author Murphy, George E.
Swift, Homer F.
author_facet Murphy, George E.
Swift, Homer F.
author_sort Murphy, George E.
collection PubMed
description Cardiac lesions like those characteristic of rheumatic fever in man have been induced in a small portion of rabbits that were subjected to successive focal infections with group A streptococci of several serological types. Fresh myocardial interstitial granulomata so induced bear striking resemblance to Aschoff bodies, the histologic hallmarks of human active rheumatic fever; and the fresh and healed lesions found in the cardiac valves, endocardia, epicardia, blood vessels, and aortae of some of these rabbits are homologous with those characteristic of rheumatic fever in man. These experimental myocardial and vascular lesions and those of human rheumatic fever differ in several important respects from the lesions of experimental and human serum disease.
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spelling pubmed-21359812008-04-17 THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE Murphy, George E. Swift, Homer F. J Exp Med Article Cardiac lesions like those characteristic of rheumatic fever in man have been induced in a small portion of rabbits that were subjected to successive focal infections with group A streptococci of several serological types. Fresh myocardial interstitial granulomata so induced bear striking resemblance to Aschoff bodies, the histologic hallmarks of human active rheumatic fever; and the fresh and healed lesions found in the cardiac valves, endocardia, epicardia, blood vessels, and aortae of some of these rabbits are homologous with those characteristic of rheumatic fever in man. These experimental myocardial and vascular lesions and those of human rheumatic fever differ in several important respects from the lesions of experimental and human serum disease. The Rockefeller University Press 1950-05-01 /pmc/articles/PMC2135981/ /pubmed/15415504 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Murphy, George E.
Swift, Homer F.
THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE
title THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE
title_full THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE
title_fullStr THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE
title_full_unstemmed THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE
title_short THE INDUCTION OF RHEUMATIC-LIKE CARDIAC LESIONS IN RABBITS BY REPEATED FOCAL INFECTIONS WITH GROUP A STREPTOCOCCI : COMPARISON WITH THE CARDIAC LESIONS OF SERUM DISEASE
title_sort induction of rheumatic-like cardiac lesions in rabbits by repeated focal infections with group a streptococci : comparison with the cardiac lesions of serum disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135981/
https://www.ncbi.nlm.nih.gov/pubmed/15415504
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