THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND

1. The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiologica...

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Autores principales: Wolfson, William Q., Cohn, Clarence, Shore, Clarice
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136004/
https://www.ncbi.nlm.nih.gov/pubmed/15428581
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author Wolfson, William Q.
Cohn, Clarence
Shore, Clarice
author_facet Wolfson, William Q.
Cohn, Clarence
Shore, Clarice
author_sort Wolfson, William Q.
collection PubMed
description 1. The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiological mechanisms involved in the anomalous purine metabolism of the Dalmatian are indicated and their possible biological significance briefly discussed. 2. A new enzymatic method for the direct estimation of true urate in biological fluids is described, which does not require the estimation of total urate and urate chromogen, followed by the calculation of true urate as a difference.
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spelling pubmed-21360042008-04-17 THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND Wolfson, William Q. Cohn, Clarence Shore, Clarice J Exp Med Article 1. The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiological mechanisms involved in the anomalous purine metabolism of the Dalmatian are indicated and their possible biological significance briefly discussed. 2. A new enzymatic method for the direct estimation of true urate in biological fluids is described, which does not require the estimation of total urate and urate chromogen, followed by the calculation of true urate as a difference. The Rockefeller University Press 1950-08-01 /pmc/articles/PMC2136004/ /pubmed/15428581 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wolfson, William Q.
Cohn, Clarence
Shore, Clarice
THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND
title THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND
title_full THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND
title_fullStr THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND
title_full_unstemmed THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND
title_short THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND
title_sort renal mechanism for urate excretion in the dalmatian coach-hound
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136004/
https://www.ncbi.nlm.nih.gov/pubmed/15428581
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