THE EFFECT OF PODOPHYLLOTOXIN, COLCHICINE, URETHANE, AND NITROGEN MUSTARD ON THE RESPIRATION OF NORMAL AND SUPRARENALECTOMIZED RAT LYMPHATIC TISSUE

The injection of podophyllotoxin, colchicine, and a nitrogen mustard derivative, methyl-bis(β-chloroethyl)amine, into normal animals causes a reduction of the respiration of the lymphatic tissues, spleen, and/or thymus. No effect was demonstrable on kidney, a representative tissue of non-lymphatic o...

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Detalles Bibliográficos
Autores principales: Miller, Zelma Baker, Davison, Clarke, Smith, Paul K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136009/
https://www.ncbi.nlm.nih.gov/pubmed/15428580
Descripción
Sumario:The injection of podophyllotoxin, colchicine, and a nitrogen mustard derivative, methyl-bis(β-chloroethyl)amine, into normal animals causes a reduction of the respiration of the lymphatic tissues, spleen, and/or thymus. No effect was demonstrable on kidney, a representative tissue of non-lymphatic origin. The degree of inhibition was considerably less in suprarenalectomized animals, suggesting that the inhibition is mediated by the suprarenal gland.

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