THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS

The effect of acid diets, fasting, and dehydration on the urine pH and the kidneys was determined in 11 control animals. Hyaline casts in the collecting tubules and interstitial medullary edema were observed in the 8 that survived. The test rabbits were subjected to the same treatment as the control...

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Autores principales: Lalich, Joseph J., Schwartz, Seymour I.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136023/
https://www.ncbi.nlm.nih.gov/pubmed/15422093
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author Lalich, Joseph J.
Schwartz, Seymour I.
author_facet Lalich, Joseph J.
Schwartz, Seymour I.
author_sort Lalich, Joseph J.
collection PubMed
description The effect of acid diets, fasting, and dehydration on the urine pH and the kidneys was determined in 11 control animals. Hyaline casts in the collecting tubules and interstitial medullary edema were observed in the 8 that survived. The test rabbits were subjected to the same treatment as the controls but, in addition, received 1.8 gm./kilo of intravenous homologous hemoglobin. Eleven of 18 animals died of hemoglobinuric nephrosis. The rabbits which died of hemoglobinuric nephrosis exhibited significant alterations in two or more of the following: kidney weight, pigment cast accumulation, and elevations of NPN. The theories which have been advanced to explain the pathogenesis of hemoglobinuric nephrosis are evaluated in the light of the present observations. It is proposed on the basis of them that antecedent tubular damage is of primary importance in the pathogenesis of hemoglobinuric nephrosis.
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spelling pubmed-21360232008-04-17 THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS Lalich, Joseph J. Schwartz, Seymour I. J Exp Med Article The effect of acid diets, fasting, and dehydration on the urine pH and the kidneys was determined in 11 control animals. Hyaline casts in the collecting tubules and interstitial medullary edema were observed in the 8 that survived. The test rabbits were subjected to the same treatment as the controls but, in addition, received 1.8 gm./kilo of intravenous homologous hemoglobin. Eleven of 18 animals died of hemoglobinuric nephrosis. The rabbits which died of hemoglobinuric nephrosis exhibited significant alterations in two or more of the following: kidney weight, pigment cast accumulation, and elevations of NPN. The theories which have been advanced to explain the pathogenesis of hemoglobinuric nephrosis are evaluated in the light of the present observations. It is proposed on the basis of them that antecedent tubular damage is of primary importance in the pathogenesis of hemoglobinuric nephrosis. The Rockefeller University Press 1950-07-01 /pmc/articles/PMC2136023/ /pubmed/15422093 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lalich, Joseph J.
Schwartz, Seymour I.
THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS
title THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS
title_full THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS
title_fullStr THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS
title_full_unstemmed THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS
title_short THE ROLE OF ACIDURIA IN THE DEVELOPMENT OF HEMOGLOBINURIC NEPHROSIS IN DEHYDRATED RABBITS
title_sort role of aciduria in the development of hemoglobinuric nephrosis in dehydrated rabbits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136023/
https://www.ncbi.nlm.nih.gov/pubmed/15422093
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