STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG

Two viral agents have been procured from patients with infectious hepatitisin two widely separated outbreaks of the disease by transfer of acute stage serum and stool filtrates to and passage in tissue cultures of rabbit liver cells in roller tubes and minced chick embryos in Simms-Sanders medium fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Henle, Werner, Harris, Susanna, Henle, Gertrude, Harris, T. N., Drake, Miles E., Mangold, Francoise, Stokes, Joseph
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1950
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136028/
https://www.ncbi.nlm.nih.gov/pubmed/15436936
_version_ 1782143033012125696
author Henle, Werner
Harris, Susanna
Henle, Gertrude
Harris, T. N.
Drake, Miles E.
Mangold, Francoise
Stokes, Joseph
author_facet Henle, Werner
Harris, Susanna
Henle, Gertrude
Harris, T. N.
Drake, Miles E.
Mangold, Francoise
Stokes, Joseph
author_sort Henle, Werner
collection PubMed
description Two viral agents have been procured from patients with infectious hepatitisin two widely separated outbreaks of the disease by transfer of acute stage serum and stool filtrates to and passage in tissue cultures of rabbit liver cells in roller tubes and minced chick embryos in Simms-Sanders medium followed by passage in the amniotic cavity of the chick. Cultures of both agents, designated the Akiba and NL strains of virus, induced mild hepatitis without jaundice in the majority of volunteers tested after an incubation period of from 9 to 38 days. Although these agents have not been identified definitely as the virus of infectious hepatitis, the available evidence, as discussed, is compatible with the suggestion that such they are.
format Text
id pubmed-2136028
institution National Center for Biotechnology Information
language English
publishDate 1950
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21360282008-04-17 STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG Henle, Werner Harris, Susanna Henle, Gertrude Harris, T. N. Drake, Miles E. Mangold, Francoise Stokes, Joseph J Exp Med Article Two viral agents have been procured from patients with infectious hepatitisin two widely separated outbreaks of the disease by transfer of acute stage serum and stool filtrates to and passage in tissue cultures of rabbit liver cells in roller tubes and minced chick embryos in Simms-Sanders medium followed by passage in the amniotic cavity of the chick. Cultures of both agents, designated the Akiba and NL strains of virus, induced mild hepatitis without jaundice in the majority of volunteers tested after an incubation period of from 9 to 38 days. Although these agents have not been identified definitely as the virus of infectious hepatitis, the available evidence, as discussed, is compatible with the suggestion that such they are. The Rockefeller University Press 1950-09-01 /pmc/articles/PMC2136028/ /pubmed/15436936 Text en Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Henle, Werner
Harris, Susanna
Henle, Gertrude
Harris, T. N.
Drake, Miles E.
Mangold, Francoise
Stokes, Joseph
STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG
title STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG
title_full STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG
title_fullStr STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG
title_full_unstemmed STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG
title_short STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS : I. PROPAGATION OF THE AGENT IN TISSUE CULTURE AND IN THE EMBRYONATED HEN'S EGG
title_sort studies on the agent of infectious hepatitis : i. propagation of the agent in tissue culture and in the embryonated hen's egg
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136028/
https://www.ncbi.nlm.nih.gov/pubmed/15436936
work_keys_str_mv AT henlewerner studiesontheagentofinfectioushepatitisipropagationoftheagentintissuecultureandintheembryonatedhensegg
AT harrissusanna studiesontheagentofinfectioushepatitisipropagationoftheagentintissuecultureandintheembryonatedhensegg
AT henlegertrude studiesontheagentofinfectioushepatitisipropagationoftheagentintissuecultureandintheembryonatedhensegg
AT harristn studiesontheagentofinfectioushepatitisipropagationoftheagentintissuecultureandintheembryonatedhensegg
AT drakemilese studiesontheagentofinfectioushepatitisipropagationoftheagentintissuecultureandintheembryonatedhensegg
AT mangoldfrancoise studiesontheagentofinfectioushepatitisipropagationoftheagentintissuecultureandintheembryonatedhensegg
AT stokesjoseph studiesontheagentofinfectioushepatitisipropagationoftheagentintissuecultureandintheembryonatedhensegg

Ejemplares similares