MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION

1. Administration of renin to the rat causes an increase in the glomerular permeability to hemoglobin and a decrease in tubular absorption of this substance as measured by functional methods. 2. Morphologic examination in the rat and in the rabbit reveals an increased concentration of hemoglobin in...

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Autores principales: Lippman, Richard W., Ureen, Helen J., Oliver, Jean
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136071/
https://www.ncbi.nlm.nih.gov/pubmed/14832405
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author Lippman, Richard W.
Ureen, Helen J.
Oliver, Jean
author_facet Lippman, Richard W.
Ureen, Helen J.
Oliver, Jean
author_sort Lippman, Richard W.
collection PubMed
description 1. Administration of renin to the rat causes an increase in the glomerular permeability to hemoglobin and a decrease in tubular absorption of this substance as measured by functional methods. 2. Morphologic examination in the rat and in the rabbit reveals an increased concentration of hemoglobin in the tubular lumina, confirmatory evidence of increased permeability. However, there is no significant effect upon the formation of hemoglobin droplets within the renal cells. 3. By analogy with the events observed in neutral red "secretion," it is suggested that hemoglobin is absorbed by both a "direct" and an "indirect" mechanism and that renin administration affects or depresses the "direct" mechanism only.
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spelling pubmed-21360712008-04-17 MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION Lippman, Richard W. Ureen, Helen J. Oliver, Jean J Exp Med Article 1. Administration of renin to the rat causes an increase in the glomerular permeability to hemoglobin and a decrease in tubular absorption of this substance as measured by functional methods. 2. Morphologic examination in the rat and in the rabbit reveals an increased concentration of hemoglobin in the tubular lumina, confirmatory evidence of increased permeability. However, there is no significant effect upon the formation of hemoglobin droplets within the renal cells. 3. By analogy with the events observed in neutral red "secretion," it is suggested that hemoglobin is absorbed by both a "direct" and an "indirect" mechanism and that renin administration affects or depresses the "direct" mechanism only. The Rockefeller University Press 1951-06-01 /pmc/articles/PMC2136071/ /pubmed/14832405 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lippman, Richard W.
Ureen, Helen J.
Oliver, Jean
MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION
title MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION
title_full MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION
title_fullStr MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION
title_full_unstemmed MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION
title_short MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION
title_sort mechanism of proteinuria : iv. effect of renin on hemoglobin excretion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136071/
https://www.ncbi.nlm.nih.gov/pubmed/14832405
work_keys_str_mv AT lippmanrichardw mechanismofproteinuriaiveffectofreninonhemoglobinexcretion
AT ureenhelenj mechanismofproteinuriaiveffectofreninonhemoglobinexcretion
AT oliverjean mechanismofproteinuriaiveffectofreninonhemoglobinexcretion

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