STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suita...

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Detalles Bibliográficos
Autores principales: Wright, George G., Hedberg, Mary A., Feinberg, Richard J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136072/
https://www.ncbi.nlm.nih.gov/pubmed/14832399
Descripción
Sumario:Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.

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