STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS

Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suita...

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Detalles Bibliográficos
Autores principales: Wright, George G., Hedberg, Mary A., Feinberg, Richard J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136072/
https://www.ncbi.nlm.nih.gov/pubmed/14832399
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author Wright, George G.
Hedberg, Mary A.
Feinberg, Richard J.
author_facet Wright, George G.
Hedberg, Mary A.
Feinberg, Richard J.
author_sort Wright, George G.
collection PubMed
description Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed.
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spelling pubmed-21360722008-04-17 STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS Wright, George G. Hedberg, Mary A. Feinberg, Richard J. J Exp Med Article Non-proteolytic mutants were isolated from the Vollum strain of B. anthracis following ultraviolet treatment. The mutants were virulent for rabbits and mice and their non-proteolytic character was stable in culture and on serial passage in rabbits. The mutants produced protective antigen under suitable conditions of cultivation in vitro, and allowed longer incubation of the cultures without destruction of the protective antigen than did the parent strain. The meaning of the results is discussed. The Rockefeller University Press 1951-06-01 /pmc/articles/PMC2136072/ /pubmed/14832399 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wright, George G.
Hedberg, Mary A.
Feinberg, Richard J.
STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS
title STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS
title_full STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS
title_fullStr STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS
title_full_unstemmed STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS
title_short STUDIES ON IMMUNITY IN ANTHRAX : II. IN VITRO ELABORATION OF PROTECTIVE ANTIGEN BY NON-PROTEOLYTIC MUTANTS OF BACILLUS ANTHRACIS
title_sort studies on immunity in anthrax : ii. in vitro elaboration of protective antigen by non-proteolytic mutants of bacillus anthracis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136072/
https://www.ncbi.nlm.nih.gov/pubmed/14832399
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