SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE

DCA was administered in two separate experiments to rats in amounts sufficient to cause marked elevation of the blood pressure. It was then abruptly withdrawn. Following this treatment, observations of blood pressure, blood urea nitrogen, plasma potassium, and plasma volume were carried out for over...

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Detalles Bibliográficos
Autores principales: Friedman, Sydney M., Friedman, Constance L., Nakashima, Miyoshi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136078/
https://www.ncbi.nlm.nih.gov/pubmed/14824408
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author Friedman, Sydney M.
Friedman, Constance L.
Nakashima, Miyoshi
author_facet Friedman, Sydney M.
Friedman, Constance L.
Nakashima, Miyoshi
author_sort Friedman, Sydney M.
collection PubMed
description DCA was administered in two separate experiments to rats in amounts sufficient to cause marked elevation of the blood pressure. It was then abruptly withdrawn. Following this treatment, observations of blood pressure, blood urea nitrogen, plasma potassium, and plasma volume were carried out for over a year. Approximately one-third of the animals so treated developed a sustained, permanent hypertension after treatment had been stopped. This sustained hypertension is not due to any anatomical fault in the kidney and in that sense is not primarily renal in origin. An hypothesis to explain the findings is presented.
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spelling pubmed-21360782008-04-17 SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE Friedman, Sydney M. Friedman, Constance L. Nakashima, Miyoshi J Exp Med Article DCA was administered in two separate experiments to rats in amounts sufficient to cause marked elevation of the blood pressure. It was then abruptly withdrawn. Following this treatment, observations of blood pressure, blood urea nitrogen, plasma potassium, and plasma volume were carried out for over a year. Approximately one-third of the animals so treated developed a sustained, permanent hypertension after treatment had been stopped. This sustained hypertension is not due to any anatomical fault in the kidney and in that sense is not primarily renal in origin. An hypothesis to explain the findings is presented. The Rockefeller University Press 1951-03-31 /pmc/articles/PMC2136078/ /pubmed/14824408 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Friedman, Sydney M.
Friedman, Constance L.
Nakashima, Miyoshi
SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE
title SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE
title_full SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE
title_fullStr SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE
title_full_unstemmed SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE
title_short SUSTAINED HYPERTENSION FOLLOWING THE ADMINISTRATION OF DESOXYCORTICOSTERONE ACETATE
title_sort sustained hypertension following the administration of desoxycorticosterone acetate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136078/
https://www.ncbi.nlm.nih.gov/pubmed/14824408
work_keys_str_mv AT friedmansydneym sustainedhypertensionfollowingtheadministrationofdesoxycorticosteroneacetate
AT friedmanconstancel sustainedhypertensionfollowingtheadministrationofdesoxycorticosteroneacetate
AT nakashimamiyoshi sustainedhypertensionfollowingtheadministrationofdesoxycorticosteroneacetate

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