THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE

Partial hepatectomies were performed on five groups of rats which had been maintained on a diet containing 4-dimethylaminoazobenzene for various lengths of time. The effect of regeneration on the incidence of hepatic tumors was compared with that in similarly treated non-hepatectomized controls. Reg...

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Detalles Bibliográficos
Autores principales: Glinos, André D., Bucher, Nancy L. R., Aub, Joseph C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136082/
https://www.ncbi.nlm.nih.gov/pubmed/14824404
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author Glinos, André D.
Bucher, Nancy L. R.
Aub, Joseph C.
author_facet Glinos, André D.
Bucher, Nancy L. R.
Aub, Joseph C.
author_sort Glinos, André D.
collection PubMed
description Partial hepatectomies were performed on five groups of rats which had been maintained on a diet containing 4-dimethylaminoazobenzene for various lengths of time. The effect of regeneration on the incidence of hepatic tumors was compared with that in similarly treated non-hepatectomized controls. Regeneration, and the time of exposure to the carcinogen as well, were relatively effective in accelerating the rate of appearance of tumors, although not markedly so. These factors were without effect on final total tumor formation. These findings support the concept that during chemical carcinogenesis tumor formation proceeds in stages.
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spelling pubmed-21360822008-04-17 THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE Glinos, André D. Bucher, Nancy L. R. Aub, Joseph C. J Exp Med Article Partial hepatectomies were performed on five groups of rats which had been maintained on a diet containing 4-dimethylaminoazobenzene for various lengths of time. The effect of regeneration on the incidence of hepatic tumors was compared with that in similarly treated non-hepatectomized controls. Regeneration, and the time of exposure to the carcinogen as well, were relatively effective in accelerating the rate of appearance of tumors, although not markedly so. These factors were without effect on final total tumor formation. These findings support the concept that during chemical carcinogenesis tumor formation proceeds in stages. The Rockefeller University Press 1951-03-31 /pmc/articles/PMC2136082/ /pubmed/14824404 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Glinos, André D.
Bucher, Nancy L. R.
Aub, Joseph C.
THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE
title THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE
title_full THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE
title_fullStr THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE
title_full_unstemmed THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE
title_short THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE
title_sort effect of liver regeneration on tumor formation in rats fed 4-dimethylaminoazobenzene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136082/
https://www.ncbi.nlm.nih.gov/pubmed/14824404
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