THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION

The comparative growth rates of a virulent (CG 179) and an avirulent (B) strain of NDV in the chicken were analyzed. Following intramuscular inoculation, the CG 179 and B strains both increased at the same rate in the extraneural tissues, i.e. the blood, lung, rectum, and spleen, but the CG 179 stra...

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Autores principales: Karzon, David T., Bang, Frederik B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136089/
https://www.ncbi.nlm.nih.gov/pubmed/14824400
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author Karzon, David T.
Bang, Frederik B.
author_facet Karzon, David T.
Bang, Frederik B.
author_sort Karzon, David T.
collection PubMed
description The comparative growth rates of a virulent (CG 179) and an avirulent (B) strain of NDV in the chicken were analyzed. Following intramuscular inoculation, the CG 179 and B strains both increased at the same rate in the extraneural tissues, i.e. the blood, lung, rectum, and spleen, but the CG 179 strain showed an accelerated growth rate in the brain. The CG 179 strain also multiplied more rapidly in the brain than the B strain following intracerebral administration of minimal inocula. Recovery with the B strain was associated with a decline in virus titer, first in the circulating blood, then in the visceral organs, and lastly in the central nervous system. Certain neuropathological observations were correlated with the pattern of virus growth.
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spelling pubmed-21360892008-04-17 THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION Karzon, David T. Bang, Frederik B. J Exp Med Article The comparative growth rates of a virulent (CG 179) and an avirulent (B) strain of NDV in the chicken were analyzed. Following intramuscular inoculation, the CG 179 and B strains both increased at the same rate in the extraneural tissues, i.e. the blood, lung, rectum, and spleen, but the CG 179 strain showed an accelerated growth rate in the brain. The CG 179 strain also multiplied more rapidly in the brain than the B strain following intracerebral administration of minimal inocula. Recovery with the B strain was associated with a decline in virus titer, first in the circulating blood, then in the visceral organs, and lastly in the central nervous system. Certain neuropathological observations were correlated with the pattern of virus growth. The Rockefeller University Press 1951-02-28 /pmc/articles/PMC2136089/ /pubmed/14824400 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Karzon, David T.
Bang, Frederik B.
THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION
title THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION
title_full THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION
title_fullStr THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION
title_full_unstemmed THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION
title_short THE PATHOGENESIS OF INFECTION WITH A VIRULENT (CG 179) AND AN AVIRULENT (B) STRAIN OF NEWCASTLE DISEASE VIRUS IN THE CHICKEN : I. COMPARATIVE RATES OF VIRAL MULTIPLICATION
title_sort pathogenesis of infection with a virulent (cg 179) and an avirulent (b) strain of newcastle disease virus in the chicken : i. comparative rates of viral multiplication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136089/
https://www.ncbi.nlm.nih.gov/pubmed/14824400
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