A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS

A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized wi...

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Detalles Bibliográficos
Autores principales: Casals, Jordi, Olitsky, Peter K., Anslow, Ralph O.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136099/
https://www.ncbi.nlm.nih.gov/pubmed/14861374
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author Casals, Jordi
Olitsky, Peter K.
Anslow, Ralph O.
author_facet Casals, Jordi
Olitsky, Peter K.
Anslow, Ralph O.
author_sort Casals, Jordi
collection PubMed
description A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. Twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were positive and 6 of 22 from apparently normal persons having Lansing-neutralizing antibody, while this held true for only 1 of 19 from those having no Lansing-neutralizing antibody. The fact that positive results were found in sera from patients having an infection with poliomyelitis virus of the Brunhilde type and at the same time no Lansing-neutralizing antibody brings up the possibility of the existence of a cross-reaction in complement fixation between the two types.
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spelling pubmed-21360992008-04-17 A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS Casals, Jordi Olitsky, Peter K. Anslow, Ralph O. J Exp Med Article A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. Twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were positive and 6 of 22 from apparently normal persons having Lansing-neutralizing antibody, while this held true for only 1 of 19 from those having no Lansing-neutralizing antibody. The fact that positive results were found in sera from patients having an infection with poliomyelitis virus of the Brunhilde type and at the same time no Lansing-neutralizing antibody brings up the possibility of the existence of a cross-reaction in complement fixation between the two types. The Rockefeller University Press 1951-08-01 /pmc/articles/PMC2136099/ /pubmed/14861374 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Casals, Jordi
Olitsky, Peter K.
Anslow, Ralph O.
A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS
title A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS
title_full A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS
title_fullStr A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS
title_full_unstemmed A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS
title_short A SPECIFIC COMPLEMENT-FIXATION TEST FOR INFECTION WITH POLIOMYELITIS VIRUS
title_sort specific complement-fixation test for infection with poliomyelitis virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136099/
https://www.ncbi.nlm.nih.gov/pubmed/14861374
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