ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE

By means of rapid serial passages, including 3 successive "blind" passages, the MEF1 strain, a Lansing-type poliomyelitis virus, has been adapted to new-born mice. The virus can readily be propagated in newborn mice, in which fully adapted virus induces in almost all inoculated animals the...

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Detalles Bibliográficos
Autores principales: Casals, Jordi, Olitsky, Peter K., Anslow, Ralph O.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136100/
https://www.ncbi.nlm.nih.gov/pubmed/14861373
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author Casals, Jordi
Olitsky, Peter K.
Anslow, Ralph O.
author_facet Casals, Jordi
Olitsky, Peter K.
Anslow, Ralph O.
author_sort Casals, Jordi
collection PubMed
description By means of rapid serial passages, including 3 successive "blind" passages, the MEF1 strain, a Lansing-type poliomyelitis virus, has been adapted to new-born mice. The virus can readily be propagated in newborn mice, in which fully adapted virus induces in almost all inoculated animals the experimental disease, resulting in a much greater infectivity for the central nervous system and a uniformly short and regular incubation period.
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spelling pubmed-21361002008-04-17 ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE Casals, Jordi Olitsky, Peter K. Anslow, Ralph O. J Exp Med Article By means of rapid serial passages, including 3 successive "blind" passages, the MEF1 strain, a Lansing-type poliomyelitis virus, has been adapted to new-born mice. The virus can readily be propagated in newborn mice, in which fully adapted virus induces in almost all inoculated animals the experimental disease, resulting in a much greater infectivity for the central nervous system and a uniformly short and regular incubation period. The Rockefeller University Press 1951-08-01 /pmc/articles/PMC2136100/ /pubmed/14861373 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Casals, Jordi
Olitsky, Peter K.
Anslow, Ralph O.
ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE
title ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE
title_full ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE
title_fullStr ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE
title_full_unstemmed ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE
title_short ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE
title_sort adaptation of a lansing strain of poliomyelitis virus to newborn mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136100/
https://www.ncbi.nlm.nih.gov/pubmed/14861373
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