MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)

Infectious NDV particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. The lesions are indistinguishable from those of influenza A virus infection. This effect of NDV was blocked by intranasal injection of RDE or immune serum before virus...

Descripción completa

Detalles Bibliográficos
Autor principal: Ginsberg, Harold S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1951
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136108/
https://www.ncbi.nlm.nih.gov/pubmed/14861378
_version_ 1782143051560386560
author Ginsberg, Harold S.
author_facet Ginsberg, Harold S.
author_sort Ginsberg, Harold S.
collection PubMed
description Infectious NDV particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. The lesions are indistinguishable from those of influenza A virus infection. This effect of NDV was blocked by intranasal injection of RDE or immune serum before virus inoculation, but not by immune serum injected 5 minutes or more after NDV. Influenza A virus infection did not diminish fixation of NDV in excised lungs but did interfere with the injurious action of this agent in the living mouse. The analogy between these reactions and those which take place in a progressive virus infection is pointed out, and the mechanism of production of lesions in virus pneumonias discussed.
format Text
id pubmed-2136108
institution National Center for Biotechnology Information
language English
publishDate 1951
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21361082008-04-17 MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV) Ginsberg, Harold S. J Exp Med Article Infectious NDV particles produce extensive pulmonary consolidation in the mouse in the absence of demonstrable virus multiplication. The lesions are indistinguishable from those of influenza A virus infection. This effect of NDV was blocked by intranasal injection of RDE or immune serum before virus inoculation, but not by immune serum injected 5 minutes or more after NDV. Influenza A virus infection did not diminish fixation of NDV in excised lungs but did interfere with the injurious action of this agent in the living mouse. The analogy between these reactions and those which take place in a progressive virus infection is pointed out, and the mechanism of production of lesions in virus pneumonias discussed. The Rockefeller University Press 1951-09-01 /pmc/articles/PMC2136108/ /pubmed/14861378 Text en Copyright © Copyright, 1951, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ginsberg, Harold S.
MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)
title MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)
title_full MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)
title_fullStr MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)
title_full_unstemmed MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)
title_short MECHANISM OF PRODUCTION OF PULMONARY LESIONS IN MICE BY NEWCASTLE DISEASE VIRUS (NDV)
title_sort mechanism of production of pulmonary lesions in mice by newcastle disease virus (ndv)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136108/
https://www.ncbi.nlm.nih.gov/pubmed/14861378
work_keys_str_mv AT ginsbergharolds mechanismofproductionofpulmonarylesionsinmicebynewcastlediseasevirusndv

Ejemplares similares