STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME

Calcium ions accelerated the activation of the proteolytic enzyme of plasma from its precursor in the globulin fraction. Calcium did not appear to potentiate fibrinolysis by active bovine or human plasma proteolytic enzyme, nor did it accelerate the activation of the precursor of this enzyme by chlo...

Descripción completa

Detalles Bibliográficos
Autor principal: Ratnoff, Oscar D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1952
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136147/
https://www.ncbi.nlm.nih.gov/pubmed/12981217
_version_ 1782143060625326080
author Ratnoff, Oscar D.
author_facet Ratnoff, Oscar D.
author_sort Ratnoff, Oscar D.
collection PubMed
description Calcium ions accelerated the activation of the proteolytic enzyme of plasma from its precursor in the globulin fraction. Calcium did not appear to potentiate fibrinolysis by active bovine or human plasma proteolytic enzyme, nor did it accelerate the activation of the precursor of this enzyme by chloroform or by streptokinase. Experiments with partially purified plasma proteolytic enzyme suggested that the acceleratory effect of calcium was mediated indirectly. Since the concentration of calcium which was effective was comparable to that present in plasma, it is possible that the phenomena reported are of biological significance.
format Text
id pubmed-2136147
institution National Center for Biotechnology Information
language English
publishDate 1952
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21361472008-04-17 STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME Ratnoff, Oscar D. J Exp Med Article Calcium ions accelerated the activation of the proteolytic enzyme of plasma from its precursor in the globulin fraction. Calcium did not appear to potentiate fibrinolysis by active bovine or human plasma proteolytic enzyme, nor did it accelerate the activation of the precursor of this enzyme by chloroform or by streptokinase. Experiments with partially purified plasma proteolytic enzyme suggested that the acceleratory effect of calcium was mediated indirectly. Since the concentration of calcium which was effective was comparable to that present in plasma, it is possible that the phenomena reported are of biological significance. The Rockefeller University Press 1952-09-30 /pmc/articles/PMC2136147/ /pubmed/12981217 Text en Copyright © Copyright, 1952, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Ratnoff, Oscar D.
STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME
title STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME
title_full STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME
title_fullStr STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME
title_full_unstemmed STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME
title_short STUDIES ON A PROTEOLYTIC ENZYME IN HUMAN PLASMA : VIII. THE EFFECT OF CALCIUM AND STRONTIUM IONS ON THE ACTIVATION OF THE PLASMA PROTEOLYTIC ENZYME
title_sort studies on a proteolytic enzyme in human plasma : viii. the effect of calcium and strontium ions on the activation of the plasma proteolytic enzyme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136147/
https://www.ncbi.nlm.nih.gov/pubmed/12981217
work_keys_str_mv AT ratnoffoscard studiesonaproteolyticenzymeinhumanplasmaviiitheeffectofcalciumandstrontiumionsontheactivationoftheplasmaproteolyticenzyme
AT studiesonaproteolyticenzymeinhumanplasmaviiitheeffectofcalciumandstrontiumionsontheactivationoftheplasmaproteolyticenzyme

Ejemplares similares