THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES

The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus has been studied. The most favorable material for fractionation of the lytic enzymes was obtained by surface growth on shallow layers of liquid medium containing an acid hydrolysate of casein, glucose, and sal...

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Detalles Bibliográficos
Autor principal: McCarty, Maclyn
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1952
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136168/
https://www.ncbi.nlm.nih.gov/pubmed/13022850
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author McCarty, Maclyn
author_facet McCarty, Maclyn
author_sort McCarty, Maclyn
collection PubMed
description The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus has been studied. The most favorable material for fractionation of the lytic enzymes was obtained by surface growth on shallow layers of liquid medium containing an acid hydrolysate of casein, glucose, and salts. The results of fractionation experiments show that the potent proetolytic enzyme of Streptomyces albus is not able to lyse group A streptococci, and that the initiation of lysis is dependent upon the action of a second, non-proteolytic enzyme. The nature of the non-proteolytic enzyme has not been determined. It does not appear to be a ribonuclease or a lysozyme-like enzyme.
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spelling pubmed-21361682008-04-17 THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES McCarty, Maclyn J Exp Med Article The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus has been studied. The most favorable material for fractionation of the lytic enzymes was obtained by surface growth on shallow layers of liquid medium containing an acid hydrolysate of casein, glucose, and salts. The results of fractionation experiments show that the potent proetolytic enzyme of Streptomyces albus is not able to lyse group A streptococci, and that the initiation of lysis is dependent upon the action of a second, non-proteolytic enzyme. The nature of the non-proteolytic enzyme has not been determined. It does not appear to be a ribonuclease or a lysozyme-like enzyme. The Rockefeller University Press 1952-11-30 /pmc/articles/PMC2136168/ /pubmed/13022850 Text en Copyright © Copyright, 1952, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
McCarty, Maclyn
THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES
title THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES
title_full THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES
title_fullStr THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES
title_full_unstemmed THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES
title_short THE LYSIS OF GROUP A HEMOLYTIC STREPTOCOCCI BY EXTRACELLULAR ENZYMES OF STREPTOMYCES ALBUS : I. PRODUCTION AND FRACTIONATION OF THE LYTIC ENZYMES
title_sort lysis of group a hemolytic streptococci by extracellular enzymes of streptomyces albus : i. production and fractionation of the lytic enzymes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136168/
https://www.ncbi.nlm.nih.gov/pubmed/13022850
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