THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE

Using the roller tube method of tissue culture, it has been shown that cortisone and compound F inhibit the cytotoxic action of PPD upon macrophages from the splenic tissue of tuberculous guinea pigs. Pretreatment of the cells for 24 hours with hormones before exposure to PPD was found to be essenti...

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Detalles Bibliográficos
Autores principales: Leahy, Robert H., Morgan, Herbert R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1952
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136171/
https://www.ncbi.nlm.nih.gov/pubmed/13022849
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author Leahy, Robert H.
Morgan, Herbert R.
author_facet Leahy, Robert H.
Morgan, Herbert R.
author_sort Leahy, Robert H.
collection PubMed
description Using the roller tube method of tissue culture, it has been shown that cortisone and compound F inhibit the cytotoxic action of PPD upon macrophages from the splenic tissue of tuberculous guinea pigs. Pretreatment of the cells for 24 hours with hormones before exposure to PPD was found to be essential. Estrone and desoxycorticosterone glucoside had no protective activity. Certain advantages of the tissue culture method in studies of tuberculin hypersensitivity and possible mechanisms and implications of this protective action of cortisone are discussed.
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spelling pubmed-21361712008-04-17 THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE Leahy, Robert H. Morgan, Herbert R. J Exp Med Article Using the roller tube method of tissue culture, it has been shown that cortisone and compound F inhibit the cytotoxic action of PPD upon macrophages from the splenic tissue of tuberculous guinea pigs. Pretreatment of the cells for 24 hours with hormones before exposure to PPD was found to be essential. Estrone and desoxycorticosterone glucoside had no protective activity. Certain advantages of the tissue culture method in studies of tuberculin hypersensitivity and possible mechanisms and implications of this protective action of cortisone are discussed. The Rockefeller University Press 1952-11-30 /pmc/articles/PMC2136171/ /pubmed/13022849 Text en Copyright © Copyright, 1952, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Leahy, Robert H.
Morgan, Herbert R.
THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE
title THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE
title_full THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE
title_fullStr THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE
title_full_unstemmed THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE
title_short THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE
title_sort inhibition by cortisone of the cytotoxic activity of ppd on tuberculin-hypersensitive cells in tissue culture
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136171/
https://www.ncbi.nlm.nih.gov/pubmed/13022849
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