THE EXISTENCE OF TWO FORMS OF HYPERTENSIN

Two types of hypertensin have been demonstrated by means of counter-current distribution. The first type is the product of the action of the enzyme, renin, upon its substrate and has been designated hypertensin I. It can be rapidly converted to a second approximately equally pressor compound, hypert...

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Detalles Bibliográficos
Autores principales: Skeggs, Leonard T., Marsh, Walton H., Kahn, Joseph R., Shumway, Norman P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1954
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136205/
https://www.ncbi.nlm.nih.gov/pubmed/13130799
Descripción
Sumario:Two types of hypertensin have been demonstrated by means of counter-current distribution. The first type is the product of the action of the enzyme, renin, upon its substrate and has been designated hypertensin I. It can be rapidly converted to a second approximately equally pressor compound, hypertensin II, apparently through the action of an enzyme in the plasma which requires halide or nitrate for activation. A highly purified preparation containing horse hypertensins I and II caused an elevation of blood pressure when injected into human beings.

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