Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris

In patients with pemphigus vulgaris (PV), autoantibodies against desmoglein 3 (Dsg3) cause loss of cell–cell adhesion of keratinocytes in the basal and immediate suprabasal layers of stratified squamous epithelia. The pathology, at least partially, may depend on protease release from keratinocytes,...

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Detalles Bibliográficos
Autores principales: Koch, Peter J., Mahoney, M G., Ishikawa, Hiroyasu, Pulkkinen, Leena, Uitto, Jouni, Shultz, Leonard, Murphy, George F., Whitaker-Menezes, Diana, Stanley, John R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136216/
https://www.ncbi.nlm.nih.gov/pubmed/9166409

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