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THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca(++) varies between 10(–2) M and 10(–3) M, decreasing with increasing concentrations of streptokinase. The susceptibility of the componen...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1953
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136238/ https://www.ncbi.nlm.nih.gov/pubmed/13084846 |
| Sumario: | Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca(++) varies between 10(–2) M and 10(–3) M, decreasing with increasing concentrations of streptokinase. The susceptibility of the components of complement to inactivation by plasmin is different in the presence and absence of Ca(++). C'2 and C'4 are most readily inactivated by plasmin in the presence of Ca(++), while C'1 disappears first in the absence of Ca(++). A large part of this C'1 disappearance is due to spontaneous inactivation. Similarities are pointed out between the influence of Ca(++) on the inactivation of the components of complement by antigen-antibody systems and by plasmin. |
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