THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN

Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca(++) varies between 10(–2) M and 10(–3) M, decreasing with increasing concentrations of streptokinase. The susceptibility of the componen...

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Detalles Bibliográficos
Autores principales: Lepow, Irwin H., Pillemer, Louis, Ratnoff, Oscar D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1953
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136238/
https://www.ncbi.nlm.nih.gov/pubmed/13084846
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author Lepow, Irwin H.
Pillemer, Louis
Ratnoff, Oscar D.
author_facet Lepow, Irwin H.
Pillemer, Louis
Ratnoff, Oscar D.
author_sort Lepow, Irwin H.
collection PubMed
description Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca(++) varies between 10(–2) M and 10(–3) M, decreasing with increasing concentrations of streptokinase. The susceptibility of the components of complement to inactivation by plasmin is different in the presence and absence of Ca(++). C'2 and C'4 are most readily inactivated by plasmin in the presence of Ca(++), while C'1 disappears first in the absence of Ca(++). A large part of this C'1 disappearance is due to spontaneous inactivation. Similarities are pointed out between the influence of Ca(++) on the inactivation of the components of complement by antigen-antibody systems and by plasmin.
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spelling pubmed-21362382008-04-17 THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN Lepow, Irwin H. Pillemer, Louis Ratnoff, Oscar D. J Exp Med Article Ca(++) potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca(++) varies between 10(–2) M and 10(–3) M, decreasing with increasing concentrations of streptokinase. The susceptibility of the components of complement to inactivation by plasmin is different in the presence and absence of Ca(++). C'2 and C'4 are most readily inactivated by plasmin in the presence of Ca(++), while C'1 disappears first in the absence of Ca(++). A large part of this C'1 disappearance is due to spontaneous inactivation. Similarities are pointed out between the influence of Ca(++) on the inactivation of the components of complement by antigen-antibody systems and by plasmin. The Rockefeller University Press 1953-09-01 /pmc/articles/PMC2136238/ /pubmed/13084846 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lepow, Irwin H.
Pillemer, Louis
Ratnoff, Oscar D.
THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
title THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
title_full THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
title_fullStr THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
title_full_unstemmed THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
title_short THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN
title_sort influence of calcium ions on the inactivation of human complement and its components by plasmin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136238/
https://www.ncbi.nlm.nih.gov/pubmed/13084846
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