Cargando…

THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION

The ability of an adjuvant and its individual constituents to induce the production of Cx-reactive protein in rabbits has been studied. It was found that the adjuvant stimulated rabbits to produce large amounts of the acute phase protein for 3 to 6 days. Melted aquaphor blended with saline stimulate...

Descripción completa

Detalles Bibliográficos
Autor principal: Wood, Harrison F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1953
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136248/
https://www.ncbi.nlm.nih.gov/pubmed/13096658
_version_ 1782143082932731904
author Wood, Harrison F.
author_facet Wood, Harrison F.
author_sort Wood, Harrison F.
collection PubMed
description The ability of an adjuvant and its individual constituents to induce the production of Cx-reactive protein in rabbits has been studied. It was found that the adjuvant stimulated rabbits to produce large amounts of the acute phase protein for 3 to 6 days. Melted aquaphor blended with saline stimulated the production of Cx-reactive protein for 3 or 4 days. Mineral oil was less effective in stimulating the production of the protein than either adjuvant or aquaphor. Heat-killed Jamaica strain tubercle bacilli suspended in mineral oil did not induce the Cx-protein response. The ability of subcutaneously administered adjuvant without antigen incorporated in the saline phase to potentiate the antibody response of rabbits to the intravenously administered antigens, C-reactive protein and human gamma globulin, was investigated. It was found that the adjuvant-treated animals produced more precipitating antibody to the two intravenously administered antigens than did the control animals given intravenous antigen alone.
format Text
id pubmed-2136248
institution National Center for Biotechnology Information
language English
publishDate 1953
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21362482008-04-17 THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION Wood, Harrison F. J Exp Med Article The ability of an adjuvant and its individual constituents to induce the production of Cx-reactive protein in rabbits has been studied. It was found that the adjuvant stimulated rabbits to produce large amounts of the acute phase protein for 3 to 6 days. Melted aquaphor blended with saline stimulated the production of Cx-reactive protein for 3 or 4 days. Mineral oil was less effective in stimulating the production of the protein than either adjuvant or aquaphor. Heat-killed Jamaica strain tubercle bacilli suspended in mineral oil did not induce the Cx-protein response. The ability of subcutaneously administered adjuvant without antigen incorporated in the saline phase to potentiate the antibody response of rabbits to the intravenously administered antigens, C-reactive protein and human gamma globulin, was investigated. It was found that the adjuvant-treated animals produced more precipitating antibody to the two intravenously administered antigens than did the control animals given intravenous antigen alone. The Rockefeller University Press 1953-09-30 /pmc/articles/PMC2136248/ /pubmed/13096658 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wood, Harrison F.
THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION
title THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION
title_full THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION
title_fullStr THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION
title_full_unstemmed THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION
title_short THE RELATIONSHIP BETWEEN THE ACUTE PHASE RESPONSE AND ANTIBODY PRODUCTION IN THE RABBIT : II. THE STIMULATION OF CX-REACTIVE PROTEIN RESPONSE BY CERTAIN ADJUVANTS AND THE RELATION OF THIS RESPONSE TO THE ENHANCEMENT OF ANTIBODY FORMATION
title_sort relationship between the acute phase response and antibody production in the rabbit : ii. the stimulation of cx-reactive protein response by certain adjuvants and the relation of this response to the enhancement of antibody formation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136248/
https://www.ncbi.nlm.nih.gov/pubmed/13096658
work_keys_str_mv AT woodharrisonf therelationshipbetweentheacutephaseresponseandantibodyproductionintherabbitiithestimulationofcxreactiveproteinresponsebycertainadjuvantsandtherelationofthisresponsetotheenhancementofantibodyformation
AT woodharrisonf relationshipbetweentheacutephaseresponseandantibodyproductionintherabbitiithestimulationofcxreactiveproteinresponsebycertainadjuvantsandtherelationofthisresponsetotheenhancementofantibodyformation