CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE

Sustained arterial hypertension developed in male, albino rats chronically fed diets rich in sodium chloride with demineralized drinking water available ad libitum. After 12 months of the experimental regimen a positive, linear correlation (r = 0.91) was found between the systolic blood pressure and...

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Autores principales: Meneely, George R., Tucker, Robert G., Darby, William J., Auerbach, Stewart H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1953
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136278/
https://www.ncbi.nlm.nih.gov/pubmed/13069651
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author Meneely, George R.
Tucker, Robert G.
Darby, William J.
Auerbach, Stewart H.
author_facet Meneely, George R.
Tucker, Robert G.
Darby, William J.
Auerbach, Stewart H.
author_sort Meneely, George R.
collection PubMed
description Sustained arterial hypertension developed in male, albino rats chronically fed diets rich in sodium chloride with demineralized drinking water available ad libitum. After 12 months of the experimental regimen a positive, linear correlation (r = 0.91) was found between the systolic blood pressure and the concentration of sodium chloride in the diet. A syndrome of edema and renal failure was observed in 18 per cent of the group fed at the level of 7.0 to 9.8 per cent of sodium chloride. Significant histologic changes occurred in the kidneys and certain other organs in rats consuming rations containing these levels of NaCl. The relative volume of the radiosodium space was increased in the rat by high dietary sodium chloride.
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spelling pubmed-21362782008-04-17 CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE Meneely, George R. Tucker, Robert G. Darby, William J. Auerbach, Stewart H. J Exp Med Article Sustained arterial hypertension developed in male, albino rats chronically fed diets rich in sodium chloride with demineralized drinking water available ad libitum. After 12 months of the experimental regimen a positive, linear correlation (r = 0.91) was found between the systolic blood pressure and the concentration of sodium chloride in the diet. A syndrome of edema and renal failure was observed in 18 per cent of the group fed at the level of 7.0 to 9.8 per cent of sodium chloride. Significant histologic changes occurred in the kidneys and certain other organs in rats consuming rations containing these levels of NaCl. The relative volume of the radiosodium space was increased in the rat by high dietary sodium chloride. The Rockefeller University Press 1953-07-01 /pmc/articles/PMC2136278/ /pubmed/13069651 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Meneely, George R.
Tucker, Robert G.
Darby, William J.
Auerbach, Stewart H.
CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE
title CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE
title_full CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE
title_fullStr CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE
title_full_unstemmed CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE
title_short CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT : II. OCCURRENCE OF HYPERTENSION AND OF A SYNDROME OF EDEMA AND RENAL FAILURE
title_sort chronic sodium chloride toxicity in the albino rat : ii. occurrence of hypertension and of a syndrome of edema and renal failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136278/
https://www.ncbi.nlm.nih.gov/pubmed/13069651
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