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THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE

Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the les...

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Autor principal: Germuth, Frederick G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1953
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136279/
https://www.ncbi.nlm.nih.gov/pubmed/13069645
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author Germuth, Frederick G.
author_facet Germuth, Frederick G.
author_sort Germuth, Frederick G.
collection PubMed
description Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the lesions were less extensive, but the percentage of animals affected was unchanged. Cortisone in the dosage employed had no effect on the elimination of antigen following its intravenous administration or on the appearance of circulating antibody. These findings indicate that inhibition of the lesions of serum sickness by cortisone does not depend on the suppression of antibody production. Therefore, it is inferred that cortisone somehow protects the animal from the damaging effects of antigen-antibody union.
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spelling pubmed-21362792008-04-17 THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE Germuth, Frederick G. J Exp Med Article Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the lesions were less extensive, but the percentage of animals affected was unchanged. Cortisone in the dosage employed had no effect on the elimination of antigen following its intravenous administration or on the appearance of circulating antibody. These findings indicate that inhibition of the lesions of serum sickness by cortisone does not depend on the suppression of antibody production. Therefore, it is inferred that cortisone somehow protects the animal from the damaging effects of antigen-antibody union. The Rockefeller University Press 1953-07-01 /pmc/articles/PMC2136279/ /pubmed/13069645 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Germuth, Frederick G.
THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
title THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
title_full THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
title_fullStr THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
title_full_unstemmed THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
title_short THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
title_sort mechanism of action of cortisone in experimental hypersensitivity : ii. hypersensitivity of the serum sickness type
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136279/
https://www.ncbi.nlm.nih.gov/pubmed/13069645
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