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THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE
Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the les...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1953
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136279/ https://www.ncbi.nlm.nih.gov/pubmed/13069645 |
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author | Germuth, Frederick G. |
author_facet | Germuth, Frederick G. |
author_sort | Germuth, Frederick G. |
collection | PubMed |
description | Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the lesions were less extensive, but the percentage of animals affected was unchanged. Cortisone in the dosage employed had no effect on the elimination of antigen following its intravenous administration or on the appearance of circulating antibody. These findings indicate that inhibition of the lesions of serum sickness by cortisone does not depend on the suppression of antibody production. Therefore, it is inferred that cortisone somehow protects the animal from the damaging effects of antigen-antibody union. |
format | Text |
id | pubmed-2136279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1953 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21362792008-04-17 THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE Germuth, Frederick G. J Exp Med Article Cortisone markedly suppressed the cardiovascular and renal lesions of serum sickness type hypersensitivity which ordinarily develop following the intravenous injection of bovine albumin. The inhibitory effect of cortisone on the allergic granulomatous lesions of the spleen was less striking; the lesions were less extensive, but the percentage of animals affected was unchanged. Cortisone in the dosage employed had no effect on the elimination of antigen following its intravenous administration or on the appearance of circulating antibody. These findings indicate that inhibition of the lesions of serum sickness by cortisone does not depend on the suppression of antibody production. Therefore, it is inferred that cortisone somehow protects the animal from the damaging effects of antigen-antibody union. The Rockefeller University Press 1953-07-01 /pmc/articles/PMC2136279/ /pubmed/13069645 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Germuth, Frederick G. THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE |
title | THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE |
title_full | THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE |
title_fullStr | THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE |
title_full_unstemmed | THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE |
title_short | THE MECHANISM OF ACTION OF CORTISONE IN EXPERIMENTAL HYPERSENSITIVITY : II. HYPERSENSITIVITY OF THE SERUM SICKNESS TYPE |
title_sort | mechanism of action of cortisone in experimental hypersensitivity : ii. hypersensitivity of the serum sickness type |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136279/ https://www.ncbi.nlm.nih.gov/pubmed/13069645 |
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