OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID

Accumulation of cholate in plasma is the immediate cause of hypercholesteremia in the rat with bile duct ligation and in the normal rat given intravenous sodium cholate. The hypercholesteremia induced by cholate administration does not appear to be dependent upon any preceding change in the rates of...

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Detalles Bibliográficos
Autores principales: Byers, Sanford O., Friedman, Meyer, Biggs, Max W., Gunning, Barbara
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1953
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136292/
https://www.ncbi.nlm.nih.gov/pubmed/13052817
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author Byers, Sanford O.
Friedman, Meyer
Biggs, Max W.
Gunning, Barbara
author_facet Byers, Sanford O.
Friedman, Meyer
Biggs, Max W.
Gunning, Barbara
author_sort Byers, Sanford O.
collection PubMed
description Accumulation of cholate in plasma is the immediate cause of hypercholesteremia in the rat with bile duct ligation and in the normal rat given intravenous sodium cholate. The hypercholesteremia induced by cholate administration does not appear to be dependent upon any preceding change in the rates of absorption, excretion, synthesis, or redistribution of cholesterol in the tissues of the animal. Cholate administration seems to induce hypercholesteremia by impeding the normal rate of passage of cholesterol from the plasma into the liver; this impedance is probably due to an alteration of the cholesterol-binding power of plasma proteins induced by cholate. The chemical and physiological implications of this finding are discussed.
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spelling pubmed-21362922008-04-17 OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID Byers, Sanford O. Friedman, Meyer Biggs, Max W. Gunning, Barbara J Exp Med Article Accumulation of cholate in plasma is the immediate cause of hypercholesteremia in the rat with bile duct ligation and in the normal rat given intravenous sodium cholate. The hypercholesteremia induced by cholate administration does not appear to be dependent upon any preceding change in the rates of absorption, excretion, synthesis, or redistribution of cholesterol in the tissues of the animal. Cholate administration seems to induce hypercholesteremia by impeding the normal rate of passage of cholesterol from the plasma into the liver; this impedance is probably due to an alteration of the cholesterol-binding power of plasma proteins induced by cholate. The chemical and physiological implications of this finding are discussed. The Rockefeller University Press 1953-03-31 /pmc/articles/PMC2136292/ /pubmed/13052817 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Byers, Sanford O.
Friedman, Meyer
Biggs, Max W.
Gunning, Barbara
OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID
title OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID
title_full OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID
title_fullStr OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID
title_full_unstemmed OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID
title_short OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS : IX. THE MECHANISM OF THE HYPERCHOLESTEREMIC EFFECT OF CHOLIC ACID
title_sort observations concerning the production and excretion of cholesterol in mammals : ix. the mechanism of the hypercholesteremic effect of cholic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136292/
https://www.ncbi.nlm.nih.gov/pubmed/13052817
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