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NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3)

Neutralization experiments with Newcastle disease, influenza A, or bacterial virus, T(3), reveal, under all conditions studied, a linear relationship between the logarithm of the serum dilution end point and that of the quantity of virus used. With Newcastle disease and influenza A, the slope of the...

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Detalles Bibliográficos
Autores principales: Tyrrell, David A. J., Horsfall, Frank L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1953
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136315/
https://www.ncbi.nlm.nih.gov/pubmed/13069640
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author Tyrrell, David A. J.
Horsfall, Frank L.
author_facet Tyrrell, David A. J.
Horsfall, Frank L.
author_sort Tyrrell, David A. J.
collection PubMed
description Neutralization experiments with Newcastle disease, influenza A, or bacterial virus, T(3), reveal, under all conditions studied, a linear relationship between the logarithm of the serum dilution end point and that of the quantity of virus used. With Newcastle disease and influenza A, the slope of the neutralization line varies markedly with the host-cell system used and in the chick embryo is strikingly affected by the route of inoculation. The other variables examined have no definite effect upon the slope. Reactivation of neutralized influenza virus is demonstrable in the chick embryo on dilution of the mixture. There appears to be an inverse relationship between the degree of susceptibility of a host to infection with influenza A virus and the neutralizing titer of a serum as measured in that host. With the T(3)-serum system, comparable results are obtained when the number of unneutralized virus particles chosen as the end point is varied widely.
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spelling pubmed-21363152008-04-17 NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3) Tyrrell, David A. J. Horsfall, Frank L. J Exp Med Article Neutralization experiments with Newcastle disease, influenza A, or bacterial virus, T(3), reveal, under all conditions studied, a linear relationship between the logarithm of the serum dilution end point and that of the quantity of virus used. With Newcastle disease and influenza A, the slope of the neutralization line varies markedly with the host-cell system used and in the chick embryo is strikingly affected by the route of inoculation. The other variables examined have no definite effect upon the slope. Reactivation of neutralized influenza virus is demonstrable in the chick embryo on dilution of the mixture. There appears to be an inverse relationship between the degree of susceptibility of a host to infection with influenza A virus and the neutralizing titer of a serum as measured in that host. With the T(3)-serum system, comparable results are obtained when the number of unneutralized virus particles chosen as the end point is varied widely. The Rockefeller University Press 1953-06-01 /pmc/articles/PMC2136315/ /pubmed/13069640 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Tyrrell, David A. J.
Horsfall, Frank L.
NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3)
title NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3)
title_full NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3)
title_fullStr NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3)
title_full_unstemmed NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3)
title_short NEUTRALIZATION OF VIRUSES BY HOMOLOGOUS IMMUNE SERUM : I. QUANTITATIVE STUDIES ON FACTORS WHICH AFFECT THE NEUTRALIZATION REACTION WITH NEWCASTLE DISEASE, INFLUENZA A, AND BACTERIAL VIRUS, T(3)
title_sort neutralization of viruses by homologous immune serum : i. quantitative studies on factors which affect the neutralization reaction with newcastle disease, influenza a, and bacterial virus, t(3)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136315/
https://www.ncbi.nlm.nih.gov/pubmed/13069640
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