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THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS

The passive Arthus arthritis in the guinea pig provides an experimental model for studying reactions comparable to those which occur in rheumatic fever. The joint swelling in the Arthus reaction is followed by tissue injury which is reflected 24 hours later by a rise in the DPA level. The height of...

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Detalles Bibliográficos
Autores principales: Coburn, Alvin F., Haninger, Joan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1954
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136324/
https://www.ncbi.nlm.nih.gov/pubmed/13118059
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author Coburn, Alvin F.
Haninger, Joan
author_facet Coburn, Alvin F.
Haninger, Joan
author_sort Coburn, Alvin F.
collection PubMed
description The passive Arthus arthritis in the guinea pig provides an experimental model for studying reactions comparable to those which occur in rheumatic fever. The joint swelling in the Arthus reaction is followed by tissue injury which is reflected 24 hours later by a rise in the DPA level. The height of this rise is determined by the degree of injury, which in turn is determined both by the strength of the antibody injected and also by the number of antigen depots created. The swelling reaction and the DPA rise can be suppressed by sodium salicylate, cortisone, or splenin A. The amount of drug required to block a DPA rise (DPA unit) is approximately tenfold the amount required to inhibit the joint swelling by 50 per cent (Arthus unit). Even when the Arthus arthritis has completed the swelling phase, treatment with appropriate amounts of these drugs suppress a rise in DPA. It was pointed out that the DPA rise appears to be associated with the tissue injury that follows joint swelling; that the degree of a DPA rise is determined by the severity of the inflammatory process; and that the amount of an anti-inflammatory agent required to suppress a DPA rise depends on the intensity of the reaction.
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spelling pubmed-21363242008-04-17 THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS Coburn, Alvin F. Haninger, Joan J Exp Med Article The passive Arthus arthritis in the guinea pig provides an experimental model for studying reactions comparable to those which occur in rheumatic fever. The joint swelling in the Arthus reaction is followed by tissue injury which is reflected 24 hours later by a rise in the DPA level. The height of this rise is determined by the degree of injury, which in turn is determined both by the strength of the antibody injected and also by the number of antigen depots created. The swelling reaction and the DPA rise can be suppressed by sodium salicylate, cortisone, or splenin A. The amount of drug required to block a DPA rise (DPA unit) is approximately tenfold the amount required to inhibit the joint swelling by 50 per cent (Arthus unit). Even when the Arthus arthritis has completed the swelling phase, treatment with appropriate amounts of these drugs suppress a rise in DPA. It was pointed out that the DPA rise appears to be associated with the tissue injury that follows joint swelling; that the degree of a DPA rise is determined by the severity of the inflammatory process; and that the amount of an anti-inflammatory agent required to suppress a DPA rise depends on the intensity of the reaction. The Rockefeller University Press 1954-01-01 /pmc/articles/PMC2136324/ /pubmed/13118059 Text en Copyright © Copyright, 1954, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Coburn, Alvin F.
Haninger, Joan
THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS
title THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS
title_full THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS
title_fullStr THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS
title_full_unstemmed THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS
title_short THE SERUM DIPHENYLAMINE (DPA) REACTION IN EXPERIMENTAL ARTHRITIS
title_sort serum diphenylamine (dpa) reaction in experimental arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136324/
https://www.ncbi.nlm.nih.gov/pubmed/13118059
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