SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS

A method for the establishment and maintenance of a colony of mice free of Theiler's (TO) virus has been described. This colony has been maintained since 1947 with but one instance of contamination in 1948. Studies on the susceptibility of these mice to TO virus show that smaller doses are requ...

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Detalles Bibliográficos
Autores principales: Feltz, Elmer T., Mandel, Benjamin, Racker, Efraim
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1953
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136333/
https://www.ncbi.nlm.nih.gov/pubmed/13109099
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author Feltz, Elmer T.
Mandel, Benjamin
Racker, Efraim
author_facet Feltz, Elmer T.
Mandel, Benjamin
Racker, Efraim
author_sort Feltz, Elmer T.
collection PubMed
description A method for the establishment and maintenance of a colony of mice free of Theiler's (TO) virus has been described. This colony has been maintained since 1947 with but one instance of contamination in 1948. Studies on the susceptibility of these mice to TO virus show that smaller doses are required to establish an infection of the intestinal tract than of the CNS. A mutant strain of TO(B) virus has been isolated which, following oral administration to mice free of TO virus, is able to cause infection of the CNS with paralysis. When fed to stock mice that carry TO virus, this TO(B) strain does not cause paralysis or other signs of CNS infection.
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spelling pubmed-21363332008-04-17 SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS Feltz, Elmer T. Mandel, Benjamin Racker, Efraim J Exp Med Article A method for the establishment and maintenance of a colony of mice free of Theiler's (TO) virus has been described. This colony has been maintained since 1947 with but one instance of contamination in 1948. Studies on the susceptibility of these mice to TO virus show that smaller doses are required to establish an infection of the intestinal tract than of the CNS. A mutant strain of TO(B) virus has been isolated which, following oral administration to mice free of TO virus, is able to cause infection of the CNS with paralysis. When fed to stock mice that carry TO virus, this TO(B) strain does not cause paralysis or other signs of CNS infection. The Rockefeller University Press 1953-10-31 /pmc/articles/PMC2136333/ /pubmed/13109099 Text en Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Feltz, Elmer T.
Mandel, Benjamin
Racker, Efraim
SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS
title SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS
title_full SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS
title_fullStr SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS
title_full_unstemmed SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS
title_short SUSCEPTIBILITY OF MICE FREE OF THEILER'S VIRUS (TO STRAIN) TO INFECTION WITH TO VIRUS
title_sort susceptibility of mice free of theiler's virus (to strain) to infection with to virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136333/
https://www.ncbi.nlm.nih.gov/pubmed/13109099
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AT mandelbenjamin susceptibilityofmicefreeoftheilersvirustostraintoinfectionwithtovirus
AT rackerefraim susceptibilityofmicefreeoftheilersvirustostraintoinfectionwithtovirus

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