SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH

The presence of a 17β-hydroxyl group endows the simple androstane molecule with the ability to produce growth of the uterus, vagina, and prostate of the female hypophysectomized albino rat. It appears that hydrogen atoms at position 17 are of critical importance since related compounds with a ketone...

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Detalles Bibliográficos
Autores principales: Huggins, Charles, Jensen, Elwood V.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1954
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136371/
https://www.ncbi.nlm.nih.gov/pubmed/13192250
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author Huggins, Charles
Jensen, Elwood V.
author_facet Huggins, Charles
Jensen, Elwood V.
author_sort Huggins, Charles
collection PubMed
description The presence of a 17β-hydroxyl group endows the simple androstane molecule with the ability to produce growth of the uterus, vagina, and prostate of the female hypophysectomized albino rat. It appears that hydrogen atoms at position 17 are of critical importance since related compounds with a ketone group at this site are inactive. Monofunctional steroids with a hydroxyl or a ketone group at position 3 likewise are devoid of activity. If a phenolic A-ring is present in monofunctional steroids the 17β-hydroxyl group is not obligatory for growth. Proliferation of the uterus and vagina were found to follow the administration of 17-desoxyestradiol.
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spelling pubmed-21363712008-04-17 SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH Huggins, Charles Jensen, Elwood V. J Exp Med Article The presence of a 17β-hydroxyl group endows the simple androstane molecule with the ability to produce growth of the uterus, vagina, and prostate of the female hypophysectomized albino rat. It appears that hydrogen atoms at position 17 are of critical importance since related compounds with a ketone group at this site are inactive. Monofunctional steroids with a hydroxyl or a ketone group at position 3 likewise are devoid of activity. If a phenolic A-ring is present in monofunctional steroids the 17β-hydroxyl group is not obligatory for growth. Proliferation of the uterus and vagina were found to follow the administration of 17-desoxyestradiol. The Rockefeller University Press 1954-09-01 /pmc/articles/PMC2136371/ /pubmed/13192250 Text en Copyright © Copyright, 1954, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Huggins, Charles
Jensen, Elwood V.
SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH
title SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH
title_full SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH
title_fullStr SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH
title_full_unstemmed SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH
title_short SIGNIFICANCE OF THE HYDROXYL GROUPS OF STEROIDS IN PROMOTING GROWTH
title_sort significance of the hydroxyl groups of steroids in promoting growth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136371/
https://www.ncbi.nlm.nih.gov/pubmed/13192250
work_keys_str_mv AT hugginscharles significanceofthehydroxylgroupsofsteroidsinpromotinggrowth
AT jensenelwoodv significanceofthehydroxylgroupsofsteroidsinpromotinggrowth

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