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INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE
The inhibition of multiplication of one poliomyelitis virus by a poliomyelitis virus of another immunologic type has been established by using tissue cultures of monkey testes. The degree of interference varied from none, to partial, to complete, depending upon the time between inoculation of the in...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1954
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136376/ https://www.ncbi.nlm.nih.gov/pubmed/13192251 |
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author | Ledinko, Nada Melnick, Joseph L. |
author_facet | Ledinko, Nada Melnick, Joseph L. |
author_sort | Ledinko, Nada |
collection | PubMed |
description | The inhibition of multiplication of one poliomyelitis virus by a poliomyelitis virus of another immunologic type has been established by using tissue cultures of monkey testes. The degree of interference varied from none, to partial, to complete, depending upon the time between inoculation of the interfering and the challenge viruses, and the amount of each virus inoculated. Reciprocal interference was demonstrated between Types 1, 2, and 3 poliomyelitis viruses. Under conditions which resulted in complete suppression of the growth of one poliomyelitis virus by another, interference by poliomyelitis virus with the multiplication of four antigenically distinct "orphan" viruses and of three antigenically related strains of Coxsackie virus could not be demonstrated. Poliomyelitis virus rendered non-infective by formalin or by irradiation with high energy electrons or with ultraviolet light, or treated so that only traces of residual active virus remained, failed to interfere with the propagation of active homologous virus. |
format | Text |
id | pubmed-2136376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1954 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21363762008-04-17 INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE Ledinko, Nada Melnick, Joseph L. J Exp Med Article The inhibition of multiplication of one poliomyelitis virus by a poliomyelitis virus of another immunologic type has been established by using tissue cultures of monkey testes. The degree of interference varied from none, to partial, to complete, depending upon the time between inoculation of the interfering and the challenge viruses, and the amount of each virus inoculated. Reciprocal interference was demonstrated between Types 1, 2, and 3 poliomyelitis viruses. Under conditions which resulted in complete suppression of the growth of one poliomyelitis virus by another, interference by poliomyelitis virus with the multiplication of four antigenically distinct "orphan" viruses and of three antigenically related strains of Coxsackie virus could not be demonstrated. Poliomyelitis virus rendered non-infective by formalin or by irradiation with high energy electrons or with ultraviolet light, or treated so that only traces of residual active virus remained, failed to interfere with the propagation of active homologous virus. The Rockefeller University Press 1954-09-01 /pmc/articles/PMC2136376/ /pubmed/13192251 Text en Copyright © Copyright, 1954, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Ledinko, Nada Melnick, Joseph L. INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE |
title | INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE |
title_full | INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE |
title_fullStr | INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE |
title_full_unstemmed | INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE |
title_short | INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE |
title_sort | interference between poliomyelitis viruses in tissue culture |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136376/ https://www.ncbi.nlm.nih.gov/pubmed/13192251 |
work_keys_str_mv | AT ledinkonada interferencebetweenpoliomyelitisvirusesintissueculture AT melnickjosephl interferencebetweenpoliomyelitisvirusesintissueculture |