THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM

The activation of poliomyelitis virus from a "neutral" virus-antibody mixture by the addition of non-infectious virus is described. The phenomenon was demonstrated in tissue cultures using both Petri dishes and roller tubes. The reaction was found to be type-specific and a relationship bet...

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Detalles Bibliográficos
Autor principal: Krech, Ulrich
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1955
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136467/
https://www.ncbi.nlm.nih.gov/pubmed/13233455
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author Krech, Ulrich
author_facet Krech, Ulrich
author_sort Krech, Ulrich
collection PubMed
description The activation of poliomyelitis virus from a "neutral" virus-antibody mixture by the addition of non-infectious virus is described. The phenomenon was demonstrated in tissue cultures using both Petri dishes and roller tubes. The reaction was found to be type-specific and a relationship between antigen dilution and number of plaques counted was established. The relative potency of vaccine preparations determined in this system was found to be comparable to their relative potency in respect to protection-inducing activity in mice.
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spelling pubmed-21364672008-04-17 THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM Krech, Ulrich J Exp Med Article The activation of poliomyelitis virus from a "neutral" virus-antibody mixture by the addition of non-infectious virus is described. The phenomenon was demonstrated in tissue cultures using both Petri dishes and roller tubes. The reaction was found to be type-specific and a relationship between antigen dilution and number of plaques counted was established. The relative potency of vaccine preparations determined in this system was found to be comparable to their relative potency in respect to protection-inducing activity in mice. The Rockefeller University Press 1955-02-28 /pmc/articles/PMC2136467/ /pubmed/13233455 Text en Copyright © Copyright, 1955, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Krech, Ulrich
THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM
title THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM
title_full THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM
title_fullStr THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM
title_full_unstemmed THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM
title_short THE ANTIGENIC POTENCY OF NON-INFECTIOUS POLIOMYELITIS VIRUS AS DETERMINED BY ITS LIBERATING EFFECT ON ACTIVE VIRUS NEUTRALIZED BY IMMUNE SERUM
title_sort antigenic potency of non-infectious poliomyelitis virus as determined by its liberating effect on active virus neutralized by immune serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136467/
https://www.ncbi.nlm.nih.gov/pubmed/13233455
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AT krechulrich antigenicpotencyofnoninfectiouspoliomyelitisvirusasdeterminedbyitsliberatingeffectonactivevirusneutralizedbyimmuneserum

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